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      Changes in Bone Mass After Discontinuation of Preexposure Prophylaxis With Tenofovir Disoproxil Fumarate/Emtricitabine in Young Men Who Have Sex With Men: Extension Phase Results of Adolescent Trials Network Protocols 110 and 113.

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          Abstract

          Human immunodeficiency virus-seronegative men aged 15-22 years who lost bone mineral density (BMD) during tenofovir disoproxil fumarate/emtricitabine preexposure prophylaxis (PrEP) showed BMD recovery 48 weeks following PrEP discontinuation. Lumbar spine and whole body BMD z-scores remained below baseline 48 weeks off PrEP in participants aged 15-19 years. Clinical Trials Registration. NCT01772823 (ATN 110) and NCT01769456 (ATN 113).

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          Author and article information

          Journal
          Clin. Infect. Dis.
          Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
          Oxford University Press (OUP)
          1537-6591
          1058-4838
          Feb 03 2020
          : 70
          : 4
          Affiliations
          [1 ] Department of Pediatrics, Medical College of Wisconsin/Children's Hospital of Wisconsin, Milwaukee.
          [2 ] Department of Biostatistics, University of Alabama at Birmingham.
          [3 ] Department of Epidemiology, University of Alabama at Birmingham.
          [4 ] Westat, Rockville, Maryland.
          [5 ] Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora.
          [6 ] Department of Medicine, David Geffen School of Medicine, University of California Los Angeles.
          [7 ] Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
          [8 ] Department of Psychiatry, Stroger Hospital of Cook County, Chicago, Illinois.
          [9 ] Department of Medicine, University of California at San Francisco, Zuckerberg San Francisco General Hospital.
          Article
          5513182
          10.1093/cid/ciz486
          31179503
          82b33218-a204-4ca5-96dc-18945a1ee647
          History

          preexposure prophylaxis,bone mineral density,men who have sex with men,adolescents,tenofovir disoproxil fumarate

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