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      Safety and Anti-Inflammatory Activity of Curcumin: A Component of Tumeric (Curcuma longa)

      The Journal of Alternative and Complementary Medicine
      Mary Ann Liebert, Inc.

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          Most cited references22

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          Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells.

          Curcumin, a major yellow pigment and active component of turmeric, has been shown to possess anti-inflammatory and anti-cancer activities. Cyclooxygenase (COX)-2 plays an important role in colon carcinogenesis. To investigate the effect of curcumin on COX-2 expression, we treated HT-29 human colon cancer cells with various concentrations of curcumin. Curcumin inhibited the cell growth of HT-29 cells in a concentration- and time-dependent manner. Curcumin markedly inhibited the mRNA and protein expression of COX-2, but not COX-1. These data suggest that a non-toxic concentration of curcumin has a significant effect on the in vitro growth of HT-29 cells, specifically inhibits COX-2 expression, and may have value as a safe chemopreventive agent for colon cancer.
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            Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent.

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              Ferula asa-foetida and Curcuma longa in traditional medical treatment and diet in Nepal.

              Food and eating have powerful symbolic value among the hinduistically-influenced ethnic groups of Nepal. In addition, food plays a major role in the concepts of illness and curing and constitute an integral part of traditional medical prescriptions. Materials that are consumed in 0.5-1.5 g amounts in the daily diet (e.g. the spices turmeric and asafoetida) are used in minute amounts for medical purposes. Why? Three hypotheses are offered here to discuss this issue.
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                10.1089/107555303321223035

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