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      Resumen ejecutivo del documento de consenso sobre el manejo de la patología renal en pacientes con infección por VIH

      Nefrología (Madrid)
      Sociedad Española de Nefrología
      AIDS, HIV, Chronic kidney disease, Renal failure, Tenofovir, Renal toxicity, Antiretroviral therapy, Renal transplant, Sida, VIH, Enfermedad renal crónica, Insuficiencia renal, Tenfovir, Toxicidad renal, Terapia antiretroviral, Trasplante renal

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          Abstract

          El objetivo de este documento es actualizar las recomendaciones sobre la evaluación y el manejo de la afectación renal en pacientes con infección por el VIH del año 2010. La función renal debe monitorizarse en todos los pacientes e incluir la medida de la concentración sérica de creatinina, la estimación del filtrado glomerular (ecuación CKD-EPI), la medida del cociente proteína/creatinina en orina y un sedimento urinario. El estudio básico de la función tubular ha de incluir la concentración sérica de fosfato y la tira reactiva de orina (glucosuria). En ausencia de alteraciones, el cribado será anual. En pacientes tratados con tenofovir o con factores de riesgo para el desarrollo de enfermedad renal crónica (ERC), se recomienda una evaluación más frecuente. Se debe evitar el uso de antirretrovirales potencialmente nefrotóxicos en pacientes con ERC o factores de riesgo para evitar su progresión. También se revisan las indicaciones de la biopsia renal, cuándo enviar el paciente al nefrólogo y las indicaciones, evaluación y manejo del paciente en diálisis o del trasplante renal.

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          [Diagnosis, treatment and prevention of renal diseases in HIV infected patients. Recommendations of the Spanish AIDS Study Group/National AIDS Plan].

          (2010)
          The incidence of opportunistic infections and tumours in HIV-infected patients has sharply declined in the HAART era. At the same time there has been a growing increase of other diseases not directly linked to immunodeficiency. Renal diseases are an increasing cause of morbidity and mortality among HIV-infected patients. In the general population, chronic renal failure has considerable multiorgan repercussions that have particular implications in patients with HIV infection. The detection of occult or subclinical chronic kidney disease is crucial since effective measures for delaying progression exist. Furthermore, the deterioration in glomerular filtration should prompt clinicians to adjust doses of some antiretroviral agents and other drugs used for treating associated comorbidities. Suppression of viral replication, strict control of blood pressure, dyslipidemia and diabetes mellitus, and avoidance of nephrotoxic drugs in certain patients are fundamental components of programs aimed to prevent renal damage and delaying progression of chronic kidney disease in patients with HIV. Renal transplantation and dialysis have also special implications in HIV-infected patients. In this article, we summarise the updated clinical practice guidelines for the evaluation, management and prevention of renal diseases in HIV-infected patients from a panel of experts in HIV and nephrologists on behalf of the Spanish AIDS Study Group (GESIDA) and the National AIDS Plan. Copyright © 2009 Elsevier España, S.L. All rights reserved.
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            Diagnosis, treatment and prevention of renal diseases in HIV infected patients: Recommendations of the Spanish AIDS Study Group/National AIDS Plan

            (2010)
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              Jerarquización del conocimiento científico. El sistema GRADE

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                Author and article information

                Journal
                S0211-69952014000600012
                10.3265/Nefrologia.pre2014.Sep.12745
                http://creativecommons.org/licenses/by/4.0/

                Urology
                AIDS,HIV,Chronic kidney disease,Renal failure,Tenofovir,Renal toxicity,Antiretroviral therapy,Renal transplant,Sida,VIH,Enfermedad renal crónica,Insuficiencia renal,Tenfovir,Toxicidad renal,Terapia antiretroviral,Trasplante renal

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