BCc1, the novel antineoplastic nanocomplex, showed potent anticancer effects in vitro and in vivo.

This international, peer-reviewed Open Access journal by Dove Medical Press focuses on the design and development of drugs, as well as the clinical outcomes, patient safety, and programs targeted at the effective and safe use of medicines. Sign up for email alerts here.

88,007 Monthly downloads/views I 4.319 Impact Factor I 6.6 CiteScore I 1.12 Source Normalized Impact per Paper (SNIP) I 0.784 Scimago Journal & Country Rank (SJR)

Record: found
Abstract: found
Article: found

Is Open Access

BCc1, the novel antineoplastic nanocomplex, showed potent anticancer effects in vitro and in vivo.

Author(s): Somayeh Kalanaky ¹ , Maryam Hafizi ² , Saideh Fakharzadeh ³ , Mohammad Vasei ⁴ , Ladan Langroudi ⁵ , Ehsan Janzamin ⁶ , Seyed Mahmoud Hashemi ⁷ , Maryam Khayamzadeh ⁸ , Masoud Soleimani ⁶ , Mohammad Esmaeil Akbari ⁸ , Mohammad Hassan Nazaran ³

Publication date (Electronic): 2016

Journal: Drug design, development and therapy

Publisher: Informa UK Limited

Keywords: BCc1, cancer, nanochelating technology, nanocomplex, nanotechnology

Read this article at

ScienceOpenPublisher PMC

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

In spite of all the efforts and researches on anticancer therapeutics, an absolute treatment is still a myth. Therefore, it is necessary to utilize novel technologies in order to synthesize smart multifunctional structures. In this study, for the first time, we have evaluated the anticancer effects of BCc1 nanocomplex by vitro and in vivo studies, which is designed based on the novel nanochelating technology.

Most cited references 39

Record: found
Abstract: found
Article: not found

Oxidative stress and cancer: an overview.

Venus Sosa, Teresa Moliné, Rosa Somoza … (2013)

Reactive species, which mainly include reactive oxygen species (ROS), are products generated as a consequence of metabolic reactions in the mitochondria of eukaryotic cells. In normal cells, low-level concentrations of these compounds are required for signal transduction before their elimination. However, cancer cells, which exhibit an accelerated metabolism, demand high ROS concentrations to maintain their high proliferation rate. Different ways of developing ROS resistance include the execution of alternative pathways, which can avoid large amounts of ROS accumulation without compromising the energy demand required by cancer cells. Examples of these processes include the guidance of the glycolytic pathway into the pentose phosphate pathway (PPP) and/or the generation of lactate instead of employing aerobic respiration in the mitochondria. Importantly, ROS levels can be used as a thermostat to monitor the damage that cells can bear. The implications for ROS regulation are highly significant for cancer therapy because commonly used radio- and chemotherapeutic drugs influence tumor outcome through ROS modulation. Moreover, the discovery of novel biomarkers that are able to predict the clinical response to pro-oxidant therapies is a crucial challenge to overcome to allow for the personalization of cancer therapies. Copyright © 2012 Elsevier B.V. All rights reserved.

0 comments Cited 467 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

CD44 is of functional importance for colorectal cancer stem cells.

Lei Du, Hongyi Wang, Leya He … (2008)

Both CD44 and CD133 were reported as putative markers for isolating colorectal cancer stem cells (CSC). It remains to be resolved if both of these markers are of functional importance for colorectal CSC. The expression of CD44 and CD133 in normal colonic tissues and primary colorectal cancer was assessed by immunohistochemistry in a series of 60 patients on tissue microarray sections. Both in vitro clonogenic and in vivo tumorigenic assay were applied to measure CSC activities from the cells isolated from patients. Lentiviral RNA interference was used to stably knock down CD44 or CD133 in colorectal cancer cells from patients. We found that CD44(+) cells displayed clustered growth and they did not colocalize with CD133(+) cells within colorectal cancer. As few as 100 CD44(+) cells from a patients' tumor initiated a xenograft tumor in vivo. A single CD44(+) cell from a tumor could form a sphere in vitro which has characteristic stem cell properties and was able to generate a xenograft tumor resembling the properties of the primary tumor. Knockdown of CD44, but not CD133, strongly prevented clonal formation and inhibited tumorigenicity in xenograft model. These results indicate that CD44 is a robust marker and is of functional importance for colorectal CSC for cancer initiation.

0 comments Cited 204 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

In vitro toxicity of silica nanoparticles in human lung cancer cells.

Weisheng Lin, Yue-Wern Huang, Xiao-Dong Zhou … (2006)

The cytotoxicity of 15-nm and 46-nm silica nanoparticles was investigated by using crystalline silica (Min-U-Sil 5) as a positive control in cultured human bronchoalveolar carcinoma-derived cells. Exposure to 15-nm or 46-nm SiO(2) nanoparticles for 48 h at dosage levels between 10 and 100 microg/ml decreased cell viability in a dose-dependent manner. Both SiO(2) nanoparticles were more cytotoxic than Min-U-Sil 5; however, the cytotoxicities of 15-nm and 46-nm silica nanoparticles were not significantly different. The 15-nm SiO(2) nanoparticles were used to determine time-dependent cytotoxicity and oxidative stress responses. Cell viability decreased significantly as a function of both nanoparticle dosage (10-100 microg/ml) and exposure time (24 h, 48 h, and 72 h). Indicators of oxidative stress and cytotoxicity, including total reactive oxygen species (ROS), glutathione, malondialdehyde, and lactate dehydrogenase, were quantitatively assessed. Exposure to SiO(2) nanoparticles increased ROS levels and reduced glutathione levels. The increased production of malondialdehyde and lactate dehydrogenase release from the cells indicated lipid peroxidation and membrane damage. In summary, exposure to SiO(2) nanoparticles results in a dose-dependent cytotoxicity in cultural human bronchoalveolar carcinoma-derived cells that is closely correlated to increased oxidative stress.

0 comments Cited 193 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Journal ID (iso-abbrev): Drug Des Devel Ther

Title: Drug design, development and therapy

Publisher: Informa UK Limited

ISSN (Electronic): 1177-8881

ISSN (Print): 1177-8881

Publication date (Electronic): 2016

Volume: 10

Affiliations

[1 ] Department of Research and Development, Sodour Ahrar Shargh Company, Tehran, Iran; Cancer Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

[2 ] Department of Research and Development, Sodour Ahrar Shargh Company, Tehran, Iran; Cancer Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Stem Cell Technology Research Center, Tehran, Iran.

[3 ] Department of Research and Development, Sodour Ahrar Shargh Company, Tehran, Iran.

[4 ] Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran.

[5 ] Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

[6 ] Department of Haematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

[7 ] Department of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

[8 ] Cancer Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Article

Publisher Item ID: dddt-10-059

DOI: 10.2147/DDDT.S89694

PMC ID: 4699513

PubMed ID: 26766901

SO-VID: 9bc521b5-c662-4865-a003-46409498067a

History

Keywords: BCc1,cancer,nanochelating technology,nanocomplex,nanotechnology

Data availability:

Keywords: BCc1, cancer, nanochelating technology, nanocomplex, nanotechnology

Comments

Comment on this article

scite_

Cited by 5

See all cited by

Most referenced authors 1,212

See all reference authors

- Version 1
- Version 1