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      Effects of early high-dose levothyroxine treatment on auditory brain event-related potentials at school entry in children with congenital hypothyroidism.

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          Abstract

          We tested whether brain event-related potentials (ERPs) are normal in children with congenital hypothyroidism (CH) after early high-dose levothyroxine treatment.

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          A behavior rating scale for the preschool child.

          Samuel Stringfield, Lenore Behar (1974)
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            Generators of the late cognitive potentials in auditory and visual oddball tasks.

            Eric Halgren, Ksenija Marinkovic, Patrick Chauvel (1998)
            Recordings directly within the brain can establish local evoked potential generation without the ambiguities always associated with extracranial electromagnetic measures. Depth recordings have found that sensory stimuli activate primary cortex and then material-specific encoders. Sensory-specific areas remain active for long periods, but by about 200 ms are joined by activation in widespread brain systems. One system is related to the orientation of attention. It is centered in paralimbic and attentional frontoparietocingular cortex, and associated with the P3a. A second system associated with P3b envelopes cognitive contextual integration. It engages the ventral temporofrontal event-encoding cortices (inferotemporal, perirhinal, and ventrolateral prefrontal), association cortices (superior temporal sulcal and posterior parietal), and the hippocampus. Thus, even in simple tasks, activation is widespread but concentrated in particular multilobar systems. With this information, the late cognitive potentials can be used to monitor the probable location, timing and intensity of brain activation during cognitive tasks.
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              Perspectives in the study of thyroid hormone action on brain development and function.

              Juan Bernal, Ana Guadaño-Ferraz, Beatriz Morte (2003)
              The purpose of this review is to provide an up-to-date report on the molecular and physiologic processes involved in the role of thyroid hormone as an epigenetic factor in brain maturation. We summarize the available data on the control of brain gene expression by thyroid hormone, the correlation between gene expression and physiologic effects, and the likely mechanisms of action of thyroid hormone on brain gene expression. In addition we propose a role for unliganded thyroid hormone receptors in the pathogenesis of hypothyroidism. Finally, we review recent data indicating that thyroid hormone receptors have an impact on behavior.
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                Author and article information

                Journal
                Journal ID (iso-abbrev): Horm. Res.
                Title: Hormone research
                Publisher: S. Karger AG
                ISSN: 0301-0163
                ISSN (Print): 0301-0163
                Publication date (Electronic): 2006
                Volume: 66
                Issue: 5
                Affiliations
                [1 ] Department of Psychiatry, Ste Justine Hospital and Research Center, Université de Montréal, Montréal, Canada.
                Article
                Publisher Item ID: 95069
                DOI: 10.1159/000095069
                PubMed ID: 16912511
                SO-VID: d338d869-16b5-4929-9bf1-7b2c6b3b884c
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