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In the present study, two new trinor-guaiane sesquiterpenes, named clavuridins B (
1 ), and A ( 2 ), along with three known sesquiterpenes ( 3–5 ), were isolated from
the Xisha soft coral Clavularia viridis . Their structures and absolute configurations
were determined on the basis of spectroscopic analysis, X-ray diffraction analysis
with Cu Kα radiation and by comparison with related model compounds. Compounds 1
and 3–5 were evaluated for their cytotoxic activity.