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      Clinical issues of mucus accumulation in COPD.

      International Journal of Chronic Obstructive Pulmonary Disease
      Informa UK Ltd.
      sputum, mucus, chronic bronchitis, chronic obstructive pulmonary disease

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          Abstract

          Airway mucus is part of the lung's native immune function that traps particulates and microorganisms, enabling their clearance from the lung by ciliary transport and cough. Mucus hypersecretion and chronic productive cough are the features of the chronic bronchitis and chronic obstructive pulmonary disease (COPD). Overproduction and hypersecretion by goblet cells and the decreased elimination of mucus are the primary mechanisms responsible for excessive mucus in chronic bronchitis. Mucus accumulation in COPD patients affects several important outcomes such as lung function, health-related quality of life, COPD exacerbations, hospitalizations, and mortality. Nonpharmacologic options for the treatment of mucus accumulation in COPD are smoking cessation and physical measures used to promote mucus clearance. Pharmacologic therapies include expectorants, mucolytics, methylxanthines, beta-adrenergic receptor agonists, anticholinergics, glucocorticoids, phosphodiesterase-4 inhibitors, antioxidants, and antibiotics.

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          Author and article information

          Journal
          24493923
          3908831
          10.2147/COPD.S38938

          sputum,mucus,chronic bronchitis,chronic obstructive pulmonary disease

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