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      Current understanding of middle east respiratory syndrome coronavirus infection in human and animal models

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          Abstract

          Middle East respiratory syndrome (MERS) is a highly lethal respiratory disease caused by a novel betacoronavirus (MERS coronavirus, MERS-CoV). Since its first emergence in 2012, multiple transmission events of MERS-CoV (dromedary to human and human to human) have been reported, indicating that MERS-CoV has the potential to cause widespread outbreak. However, the epidemiology of MERS as well as immune responses against the virus in animal models and patients are still not well understood, hindering the vaccine and therapeutic developments. In this review, we summarize recent genetic and epidemic findings of MERS-CoV and the progress in animal model development, immune response studies in both animals and humans. At last, we discussed the breakthrough on vaccine and therapeutic development which are important against potential future MERS outbreak.

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          Author and article information

          Journal
          J Thorac Dis
          J Thorac Dis
          JTD
          Journal of Thoracic Disease
          AME Publishing Company
          2072-1439
          2077-6624
          July 2018
          July 2018
          : 10
          : Suppl 19
          : S2260-S2271
          Affiliations
          [1 ]State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital , Guangzhou 510120, China;
          [2 ]Institute of Infectious disease, Guangzhou Eighth People's Hospital of Guangzhou Medical University , Guangzhou 510120, China
          Author notes

          Contributions: (I) Conception and design: J Zhao; (II) Administrative support: None; (III) Provision of study materials or patients: All authors; (IV) Collection and assembly of data: Y Wang, J Sun; (V) Data analysis and interpretation: Y Wang, J Sun, J Zhao; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

          [*]

          These authors contributed equally to this work.

          Correspondence to: Dr. Jincun Zhao. State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou Medical University, 195 Dongfeng West Road, Yuexiu District, Guangzhou 510182, China. Email: zhaojincun@ 123456gird.cn .
          Article
          PMC6072923 PMC6072923 6072923 jtd-10-S19-S2260
          10.21037/jtd.2018.03.80
          6072923
          30116605
          2018 Journal of Thoracic Disease. All rights reserved.
          Categories
          Review Article

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