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      Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China.

      Science (New York, N.Y.)
      Amino Acid Sequence, Animals, Animals, Wild, virology, Antibodies, Viral, blood, Blotting, Western, Carnivora, China, Coronavirus, classification, genetics, immunology, isolation & purification, Coronavirus Infections, veterinary, Disease Reservoirs, Feces, Genome, Viral, Humans, Membrane Glycoproteins, chemistry, Molecular Sequence Data, Neutralization Tests, Nose, Open Reading Frames, Phylogeny, Polymorphism, Genetic, Reverse Transcriptase Polymerase Chain Reaction, SARS Virus, Sequence Deletion, Sequence Homology, Nucleic Acid, Spike Glycoprotein, Coronavirus, Viral Envelope Proteins, Viral Proteins

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          A novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals (including a raccoon dog, Nyctereutes procyonoides) and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. The detection of SCoV-like viruses in small, live wild mammals in a retail market indicates a route of interspecies transmission, although the natural reservoir is not known.

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