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      Effect of a low sodium diet on urinary elimination of cystine in cystinuric children.

      1 , , ,
      Nephron
      S. Karger AG

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          Abstract

          Restriction of sodium intake has been shown to decrease urinary elimination of cystine in adult subjects with cystinuria. This simple therapeutic recommendation may be particularly useful in pediatric patients whose compliance with high fluid ingestion and repeated doses of alkali is usually poor. We studied the effect of sodium intake in 5 cystinuric children (3 males) aged 5.9-9.3 years. Urinary excretion of cystine (means +/- SD) was determined at the end of two sequential 1-week periods in which sodium content of diet was modified. Reduction of sodium intake brought about significant decreases in natriuresis (6.0 +/- 2.1 vs. 1.5 +/- 0.5 mEq/kg/day, p < 0.03) and urine cystine concentration (328.0 +/- 190.7 vs. 14.1 +/- 7.4 mg/l, p < 0.02) while urine volume output remained unchanged (58.0 +/- 36.0 vs. 70.3 +/- 33.0 ml/kg/day). These findings confirm that elimination of cystine is highly influenced by sodium intake in cystinuric children and suggest that a low sodium diet may play a key-role in the treatment of pediatric patients with cystinuria.

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          Author and article information

          Journal
          Nephron
          Nephron
          S. Karger AG
          1660-8151
          1660-8151
          1995
          : 71
          : 4
          Affiliations
          [1 ] Department of Pediatrics, Hospital Central de Asturias and School of Medicine, University of Oviedo, Spain.
          Article
          10.1159/000188761
          8587621
          42b3b7fe-4183-46f6-a8ef-406edce36a54
          History

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