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      Immunological goings-on in visceral adipose tissue.

      Cell Metabolism
      B-Lymphocytes, immunology, Diabetes Mellitus, Type 2, metabolism, Humans, Inflammation, Insulin Resistance, Intra-Abdominal Fat, Macrophages, Natural Killer T-Cells, Obesity, T-Lymphocytes

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          Abstract

          Chronic, low-grade inflammation of visceral adipose tissue, and systemically, is a critical link between recent strikingly parallel rises in the incidence of obesity and type 2 diabetes. Macrophages have been recognized for some time to be critical participants in obesity-induced inflammation of adipose tissue. Of late, a score of other cell types of the innate and adaptive arms of the immune system have been suggested to play a positive or negative role in adipose tissue infiltrates. This piece reviews the existing data on these new participants; discusses experimental uncertainties, inconsistencies, and complexities; and puts forward a minimalist synthetic scheme. Copyright © 2013 Elsevier Inc. All rights reserved.

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          Author and article information

          Journal
          23747244
          4264591
          10.1016/j.cmet.2013.05.008

          Chemistry
          B-Lymphocytes,immunology,Diabetes Mellitus, Type 2,metabolism,Humans,Inflammation,Insulin Resistance,Intra-Abdominal Fat,Macrophages,Natural Killer T-Cells,Obesity,T-Lymphocytes

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