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      Corneal biomechanical properties in healthy children measured by corneal visualization scheimpflug technology.

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          Abstract

          The aim of this study was to evaluate corneal biomechanical properties in a population of healthy children in China using corneal visualization Scheimpflug technology (CST).

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          Most cited references29

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          Determining in vivo biomechanical properties of the cornea with an ocular response analyzer.

          David Luce (2005)
          To study the results of an ocular response analyzer (ORA) to determine the biomechanical properties of the cornea and their relationship to intraocular pressure (IOP). Reichert Inc., Depew, New York, USA. The ORA (Reichert) makes 2 essentially instantaneous applanation measurements that permit determination of corneal and IOP effects. Measurements of several populations indicate that corneal hysteresis, a biomechanical measure, varied over a dynamic range of 1.8 to 14.6 mm Hg and was only weakly correlated with corneal thickness (r(2)=0.12); this is related to the observation that some subjects with relatively thick corneas have less-than-average corneal hysteresis. Corneal hysteresis changes diurnally, presumably as a result of hydration changes. Keratoconus, Fuchs' dystrophy, and post-LASIK patients demonstrated low corneal hysteresis. The corneal hysteresis biomechanical measure may prove valuable for qualification and predictions of outcomes of refractive surgery and in other cases in which corneal biomechanics are important.
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            What biomechanical properties of the cornea are relevant for the clinician?

            Although the effects of central corneal thickness and corneal curvature on intraocular pressure measurement are well known, it has only recently become possible to measure the biomechanical properties of the cornea in vivo. This article reviews the structural and material properties of the cornea and considers the effects of corneal parameters, including biomechanics, on IOP measurement. The role of corneal biomechanics as a potential indicator of the structural integrity of the globe will also be discussed. Current evidence suggests that the importance of corneal biomechanics to the glaucoma clinician rests primarily with its effects on IOP measurement. However, the possibility that corneal biomechanics may give an indication of the structural integrity of the optic nerve head cannot be completely excluded. Further population and longitudinal studies are needed to clarify whether current in vivo measures of corneal biomechanical properties, including corneal hysteresis, prove to be independent predictors of glaucoma susceptibility.
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              Collagen fibrils in the human corneal stroma: structure and aging.

              Transparency and biomechanical properties of the cornea depend on the structure and organization of collagen fibrils. The authors determined diameter, axial period, and lateral molecular spacing of collagen fibrils in human corneal stroma as a function of age. Seventeen normal human corneas were investigated in their native state by means of small-angle and wide-angle x-ray scattering. The mean radius of collagen fibrils, the axial period of collagen fibrils, and the lateral intermolecular Bragg spacing were found to be age dependent. The authors determined fibril radii of 16.1 +/- 0.5 nm in persons older than 65 years of age (n = 10) and 15.4 +/- 0.5 nm (mean +/- SD) in persons younger than 65 years (n = 7) (P 65 years) and 65.2 +/- 0.8 nm ( 65 years) and 1.499 +/- 0.013 nm (< 65 years) for the intermolecular Bragg spacing (P < 0.022). Aging is related to a three-dimensional growth of collagen fibrils in the human corneal stroma. The age-related growth of the fibril diameter was mostly a result of an increased number of collagen molecules and, in addition, to some expansion of the intermolecular Bragg spacing probably resulting from glycation-induced cross-linking. The observed expansion of the fibrils in an axial direction may result from reduction of the molecular tilting angle within collagen fibrils. The observed alterations of the collagen framework may have implications for refractive surgery and ocular tonometry achieved through related changes in the biomechanical properties of the cornea.
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                Author and article information

                Journal
                BMC Ophthalmol
                BMC ophthalmology
                Springer Nature
                1471-2415
                1471-2415
                May 17 2017
                : 17
                : 1
                Affiliations
                [1 ] Zhongshan Ophthalmic Center and State Key Laboratory of Ophthalmology, Sun Yat-sen University, 54S Xianlie Road, 510060, Guangzhou, China.
                [2 ] Hainan Eye Hospital, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou, China.
                [3 ] Zhongshan Ophthalmic Center and State Key Laboratory of Ophthalmology, Sun Yat-sen University, 54S Xianlie Road, 510060, Guangzhou, China. zhongxwu@mail.sysu.edu.cn.
                [4 ] Hainan Eye Hospital, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou, China. zhongxwu@mail.sysu.edu.cn.
                Article
                10.1186/s12886-017-0463-x
                10.1186/s12886-017-0463-x
                5436434
                28514942
                84545dc7-9927-4513-b9cb-7552b833e9df
                History

                Children,Chinese,Corneal biomechanics,Corneal deformation,Corvis ST,Symmetry

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