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      Accumulation of aluminium in patients with acute renal failure.

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      Nephron

      S. Karger AG

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          Abstract

          Serum aluminium was monitored in 19 patients admitted with acute oligo-anuric renal failure. The maximum serum aluminium obtained during the course of treatment was greater (p less than 0.05) in 4 patients treated by haemodialysis alone, mean +/- sem 3.78 +/- 0.71 mumol/l than in 4 patients treated only by haemofiltration, 0.60 +/- 0.22 greater (p less than 0.05) during treatment with haemodialysis, 2.7 +/- 0.62 mumol/l than during treatment with haemofiltration, 1.36 +/- 0.15 mumol/l. There was a significant positive correlation between the maximum serum aluminium during treatment with haemodialysis and the number of hours of haemodialysis given (r = 0.76, p less than 0.001). There was no significant increase in serum aluminium due to the administration of human albumin solutions. The aluminium content of dialysate water represents a major source of aluminium in patients with acute renal failure; prevention by reverse-osmosis water purification is recommended.

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          Author and article information

          Journal
          Nephron
          Nephron
          S. Karger AG
          1660-8151
          1660-8151
          1989
          : 52
          : 3
          Affiliations
          [1 ] Renal Unit, Royal Liverpool Hospital, UK.
          Article
          10.1159/000185652
          2739864

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