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1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT(6) receptor ligands.

Author(s): Ronald C Bernotas, Schuyler A Antane, Steven Lenicek, Simon N. Haydar, Albert Robichaud, Boyd Harrison, Guo Ming Zhang, Deborah Smith, Joseph Coupet, Lee Schechter

Publication date: 2009-12-15

Journal: Bioorganic & Medicinal Chemistry Letters

Keywords: HeLa Cells, Humans, Ligands, Pyridines, chemistry, pharmacology, Pyrroles, Receptors, Serotonin, drug effects, metabolism, Serotonin Antagonists, Serotonin Receptor Agonists

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Abstract

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines were prepared. Binding assays indicated they are 5-HT(6) receptor ligands, among which 6f and 6g showed high affinity for 5-HT(6) receptors with K(i)=3.9 and 1.7 nM, respectively.

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PubMed ID:: 19884004

DOI:: 10.1016/j.bmcl.2009.10.067

ScienceOpen disciplines: Chemistry

Keywords: HeLa Cells,Humans,Ligands,Pyridines,chemistry,pharmacology,Pyrroles,Receptors, Serotonin,drug effects,metabolism,Serotonin Antagonists,Serotonin Receptor Agonists

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ScienceOpen disciplines: Chemistry

Keywords: HeLa Cells, Humans, Ligands, Pyridines, chemistry, pharmacology, Pyrroles, Receptors, Serotonin, drug effects, metabolism, Serotonin Antagonists, Serotonin Receptor Agonists

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT(6) receptor ligands.

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