Investigation of Physicochemical Properties of PVA-GANT Mucoadhesive Hydrogels

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Abstract

The aim of this work was the manufacture and characterisation of novel chemically cross-linked mucoadhesive PVA-GANT hydrogels prepared by using autoclaving. Particularly, the study was focused on the physicochemical and pharmaceutical properties of these hydrogels with regards to potential applications for drug delivery and wound dressing. PVA-GANT hydrogels with different molar ratios and total concentrations of polymers in solution were prepared using a standard sterilisation autoclave. The physico-chemical properties were characterised by various techniques including IR spectroscopy, Texture Analysis and SEM and thermo-analytical techniques (DSC and TGA). Pharmaceutical characteristics were obtained in drug loading/release tests and microbiological assays. The results have shown that the properties of hydrogels (swelling degree, mechanical properties, internal structure, drug loading/release and antimicrobial properties) are very dependent on the polymer composition.

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Hydrogels in pharmaceutical formulations.

N. Peppas (2000)

The availability of large molecular weight protein- and peptide-based drugs due to the recent advances in the field of molecular biology has given us new ways to treat a number of diseases. Synthetic hydrogels offer a possibly effective and convenient way to administer these compounds. Hydrogels are hydrophilic, three-dimensional networks, which are able to imbibe large amounts of water or biological fluids, and thus resemble, to a large extent, a biological tissue. They are insoluble due to the presence of chemical (tie-points, junctions) and/or physical crosslinks such as entanglements and crystallites. These materials can be synthesized to respond to a number of physiological stimuli present in the body, such as pH, ionic strength and temperature. The aim of this article is to present a concise review on the applications of hydrogels in the pharmaceutical field, hydrogel characterization and analysis of drug release from such devices.

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Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-alt-maleic anhydride) mixtures for wound care applications

Julio San Román, Enrica Caló, Vitaliy Khutoryanskiy … (2016)

Novel antimicrobial hydrogels with good mechanical and physical properties were synthesized by autoclaving aqueous mixtures of poly(vinyl alcohol) and poly(methyl vinyl ether- alt -maleic anhydride). Novel antimicrobial hydrogels with good mechanical and physical properties were synthesized by autoclaving aqueous mixtures of poly(vinyl alcohol) and poly(methyl vinyl ether- alt -maleic anhydride). The structure of these materials was studied by infrared spectroscopy, scanning electron microscopy and solid state nuclear magnetic resonance. The swelling behavior, mechanical properties and adhesion of the hydrogels to porcine skin were evaluated. It was established that these hydrogels exhibited antimicrobial properties and inhibited bacteria growth against Staphylococcus aureus . The biocompatibility of the hydrogels was confirmed using an MTT assay (indirect cytotoxicity) and by monitoring cell proliferation in contact with the gels (direct cytotoxicity).