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      Regulation of DNA repair throughout the cell cycle.

      Nature reviews. Molecular cell biology
      Animals, Cell Cycle, DNA Damage, DNA Repair, Humans, Protein Kinases, metabolism, Small Ubiquitin-Related Modifier Proteins, Ubiquitination

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          Abstract

          The repair of DNA lesions that occur endogenously or in response to diverse genotoxic stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways that regulate specific DNA-repair mechanisms in the different phases of the cell cycle. Checkpoint-arrested cells resume cell-cycle progression once damage has been repaired, whereas cells with unrepairable DNA lesions undergo permanent cell-cycle arrest or apoptosis. Recent studies have provided insights into the mechanisms that contribute to DNA repair in specific cell-cycle phases and have highlighted the mechanisms that ensure cell-cycle progression or arrest in normal and cancerous cells.

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          Author and article information

          Journal
          18285803
          10.1038/nrm2351

          Chemistry
          Animals,Cell Cycle,DNA Damage,DNA Repair,Humans,Protein Kinases,metabolism,Small Ubiquitin-Related Modifier Proteins,Ubiquitination

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