Theranostic metal–organic framework core–shell composites for magnetic resonance imaging and drug delivery

A novel multifunctional MOF-based composite with good biocompatibility, high drug loading capacity, sustained drug release and outstanding MR imaging capability was developed through a simple in situ growth procedure for simultaneous drug delivery and magnetic resonance (MR) imaging. Metal–organic frameworks (MOFs) have shown great potential in designing theranostic probes for cancer diagnosis and therapy due to their unique properties, including versatile structures and composition, tunable particle and pore size, enormous porosity, high surface area, and intrinsic biodegradability. In this study, we demonstrate novel MOF-based theranostic Fe 3 O 4 @UiO-66 core–shell composites constructed by in situ growth of a UiO-66 MOF shell on a Fe 3 O 4 core for simultaneous drug delivery and magnetic resonance (MR) imaging. In the composites, the UiO-66 shell is devoted for encapsulating the drug, whereas the Fe 3 O 4 core serves as a MR contrast agent. The Fe 3 O 4 @UiO-66 core–shell composites show good biocompatibility, high drug loading capacity, sustained drug release, and outstanding MR imaging capability, as well as effective chemotherapeutic efficacy, demonstrating the feasibility of designing theranostic Fe 3 O 4 @UiO-66 core–shell composites for cancer diagnosis and therapy.