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      • Record: found
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      • Article: found

      Superoxide Dismutase Molecules in Human Cataractous Lenses

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          Abstract

          Specific activity of superoxide dismutase (SOD) in cataractous lenses was examined. Immunoprecipitation with monospecific antibodies showed an accumulation of catalytically inactive, but antigenically reactive enzyme molecules in lenses with various types of cataracts. The inactive enzyme molecules can be demonstrated in all kinds of cataracts, including dense, mature cataracts with very low or nondetectable enzyme activity. In cataracts from diabetic patients, the mean enzyme activity was higher than in nondiabetic patients. This was especially marked in nuclear cataracts, in which the specific activity of SOD was higher than in similar cataracts from nondiabetics.

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          Author and article information

          Journal
          Journal ID (publisher-id): ORE
          Journal ID (nlm-ta): Ophthalmic Res
          Journal ID (doi): 10.1159/issn.0030-3747
          Title: Ophthalmic Research
          Publisher: S. Karger AG
          ISSN (Print): 0030-3747
          ISSN (Electronic): 1423-0259
          Publication date Subscription-year: 1986
          Publication date (Print): 1986
          Publication date (Electronic): 04 December 2009
          Volume: 18
          Issue: 6
          Pages: 332-337
          Affiliations
          aDepartment of Ophthalmology, Rambam Medical Center and Faculty of Medicine, Technion; bDepartment of Biology, Technion-Israel Institute of Technology, Haifa, Israel
          Article
          Publisher ID: 265459 Other ID: Ophthalmic Res 1986;18:332–337
          DOI: 10.1159/000265459
          PubMed ID: 3299197
          SO-VID: a13bba95-929a-421e-90ba-3a1ae0b350f4
          Copyright © © 1986 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 17 February 1986
          Date accepted : 29 May 1986
          Page count
          Pages: 6
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Vision sciences,Ophthalmology & Optometry,Pathology
          Keywords: Superoxide dismutase,Immunodetection of enzymes,Human lens,Inactive enzymes,Oxidation,Cataract
          Data availability:
          ScienceOpen disciplines: Vision sciences, Ophthalmology & Optometry, Pathology
          Keywords: Superoxide dismutase, Immunodetection of enzymes, Human lens, Inactive enzymes, Oxidation, Cataract

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