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Characterization of a novel coronavirus associated with severe acute respiratory syndrome.
Paul A Rota
1 ,
M Steven Oberste ,
Stephan S Monroe ,
W Allan Nix ,
Ray Campagnoli ,
Joseph P Icenogle ,
Silvia Peñaranda ,
Bettina Bankamp ,
Kaija Maher ,
Min-Hsin Chen ,
Suxiong Tong ,
Azaibi Tamin ,
Luis Lowe ,
Michael Frace ,
Joseph L DeRisi ,
Qi Chen ,
David Wang ,
Dean D Erdman ,
Teresa C T Peret ,
Cara Burns ,
Thomas G Ksiazek ,
Pierre E Rollin ,
Anthony Sanchez ,
Stephanie Liffick ,
Brian Holloway ,
Josef Limor ,
Karen McCaustland ,
Melissa Olsen-Rasmussen ,
Ron Fouchier ,
Stephan Günther ,
Albert D M E Osterhaus ,
Christian Drosten ,
Mark A Pallansch ,
Larry J Anderson ,
William J Bellini
May 30 2003
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Abstract
In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.