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      [Calcified aortic valve disease: association with atherosclerosis].

      1 , ,
      Medicina clinica
      Elsevier BV

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          Abstract

          Calcified aortic valve disease (CAVD) is a prevalent condition, affecting 25% of people older than 65 years. CAVD and atherosclerosis share common risk factors and pathogenic mechanisms. Nevertheless, they present different pathologic lesions. The main factors involved in the pathogenesis of CAVD are genetic predisposition, the process of valvular calcification, deposition of lipoproteins, and chronic inflammation. Studies have suggested a potential benefit from early treatment with angiotensin converting enzyme inhibitors or angiotensin-II receptor blockers, and particularly with statins. Observational studies on risk factors for the CAVD, and randomized clinical trials on primary and secondary prevention in subjects with high risk for the disease, would be necessary to improve the clinical management of CAVD.

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          Author and article information

          Journal
          Med Clin (Barc)
          Medicina clinica
          Elsevier BV
          1578-8989
          0025-7753
          May 14 2011
          : 136
          : 13
          Affiliations
          [1 ] Unidad de Cardiología, Hospital Virgen de la Montaña, Cáceres, España.
          Article
          S0025-7753(10)00285-X
          10.1016/j.medcli.2010.02.019
          20417530
          6cc9a6f4-5b2b-4483-a9fe-ad539e293454
          History

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