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Abstract
Integrin is a large family of cell adhesion molecules (CAMs) which involves in the
interaction of cells/cells and cells/ extracellular matrix (ECM) to mediate cell proliferation,
differentiation, adhesion, migration, etc. In recent years, aberrant expression of
integrin has been clearly found in many tumor studies, indicating that integrin is
closely related to tumor formation and development. Meanwhile, it has effects on tumor
cell differentiation, cell migration, proliferation and tumor neovascularization.
The study of drugs targeting integrins is of great significance for the clinical treatment
of tumors. Because of its important role in tumorigenesis and development, integrin
has become a promising target for the treatment of cancer. This review summarizes
the role of integrin in tumor development and the current state of integrin inhibitors
to provide a valuable reference for subsequent research.
Author and article information
Journal
Title:
Chinese Journal of Natural Medicines
Abbreviated Title:
Chinese Journal of Natural Medicines