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      Blood eosinophil count and exacerbations in severe chronic obstructive pulmonary disease after withdrawal of inhaled corticosteroids: a post-hoc analysis of the WISDOM trial.

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          Abstract

          Blood eosinophil counts might predict response to inhaled corticosteroids (ICS) in patients with chronic obstructive pulmonary disease (COPD) and a history of exacerbations. We used data from the WISDOM trial to assess whether patients with COPD with higher blood eosinophil counts would be more likely to have exacerbations if ICS treatment was withdrawn.

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          Author and article information

          Journal
          Lancet Respir Med
          The Lancet. Respiratory medicine
          Elsevier BV
          2213-2619
          2213-2600
          May 2016
          : 4
          : 5
          Affiliations
          [1 ] Pulmonary Research Institute at Lung Clinic Grosshansdorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany. Electronic address: h.watz@pulmoresearch.de.
          [2 ] Boehringer Ingelheim Pharma GmbH and Co KG, Ingelheim, Germany; Department of Sports Medicine, University of Tübingen, Tübingen, Germany.
          [3 ] Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, Netherlands.
          [4 ] Pulmonary Research Institute at Lung Clinic Grosshansdorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany.
          [5 ] Universitat de Barcelona, Hospital Clínic IDIBAPS-CIBERES, Barcelona, Spain.
          [6 ] Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-Universität Marburg, German Center for Lung Research, Marburg, Germany.
          [7 ] Department of Metabolic Medicine, University of Modena & Reggio Emilia, Modena, NOCSAE, AUSL Modena, Baggiovara, Italy.
          [8 ] Aix-Marseille Université, Department of Respiratory Diseases and CIC Nord, AP-HM-Hôpital Nord, Marseille, France.
          [9 ] University of Southern Denmark, Odense, Denmark.
          [10 ] Boehringer Ingelheim Pharma GmbH and Co KG, Ingelheim, Germany.
          [11 ] Department of Biostatistics and Data Sciences, Boehringer Ingelheim, Bracknell, UK.
          [12 ] Institute of Ageing and Chronic Disease, Aintree University Hospital, Liverpool, UK.
          Article
          S2213-2600(16)00100-4
          10.1016/S2213-2600(16)00100-4
          27066739

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