[1
]Department of Internal Medicine, Erasmus Medical Centre Rotterdam , Rotterdam 3000CA, The Netherlands
[2
]The National Heart, Lung, and Blood Institute's and Boston University's Framingham
Heart Study , Framingham, Massachusetts 01702, USA
[3
]Population Sciences Branch, Division of Intramural Research, National Heart, Lung,
and Blood Institute , Bethesda, Maryland 20817, USA
[4
]Epidemiology and Public Health, University of Exeter Medical School , Exeter EX4 1DB, UK
[5
]Department of Functional Genomics, Interfaculty Institute for Genetics and Functional
Genomics, University Medicine Greifswald , Greifswald 17493, Germany
[6
]The Charles Bronfman Institute for Personalized Medicine, Genetics of Obesity & Related
Metabolic Traits Program, Icahn School of Medicine at Mount Sinai , One Gustave L. Levy Place, New York 10029, USA
[7
]Department of Human Genetics, School of Medicine, Emory University , Atlanta, Georgia 30301, USA
[8
]Centre for Neurogenetics and Statistical Genomics, Queensland Brain Institute, University
of Queensland , St Lucia, Brisbane, Queensland 4000, Australia
[9
]The Institute for Molecular Bioscience, University of Queensland , Brisbane, Queensland 4000, Australia
[10
]Estonian Genome Center, University of Tartu , Tartu 0794, Estonia
[11
]Nathan Shock Center of Excellence in the Basic Biology of Aging, The Jackson Laboratory , Bar Harbor, Maine 04609, USA
[12
]Department of Genetics, University Medical Center Groningen, University of Groningen , Groningen 9700RB, The Netherlands
[13
]Institute of Human Genetics, Helmholz Zentrum München - German Research Center for
Environmental Health , Neuherberg 85764, Germany
[14
]Institute of Human Genetics, Technical University Munich , Munich 85540, Germany
[15
]Neuroscience Division, Garvan Institute of Medical Research, Australia and Charles
Perkins Centre and School of Molecular Bioscience, The University of Sydney , Sydney, New South Wales 2006, Australia
[16
]Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes
and Digestive and Kidney Disease, National Institutes of Health , Phoenix, Arizona 85001, USA
[17
]Institute for Molecular Medicine Finland FIMM, University of Helsinki , Helsinki 00131, Finland
[18
]Department of Chronic Disease Prevention, National Institute for Health and Welfare , Helsinki 00131, Finland
[19
]Department of Molecular Epidemiology, Leiden University Medical Center , Leiden 2300RC, The Netherlands
[20
]Department of Genetics, Texas Biomedical Research Institute , San Antonio, Texas 78201, USA
[21
]Division of Epidemiology, Human Genetics, and Environmental Sciences, School of Public
Health, University of Texas Health Sciences , Center at Houston, Texas 77001, USA
[22
]Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston , Houston, Texas 77001, USA
[23
]Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School
of Medicine , Winston-Salem, North Carolina 27101, USA
[24
]Computational Medicine Core, Center for Lung Biology, University of Washington , Seattle, Washington 98101, USA
[25
]Section of Genetic Medicine, Institute for Genomics and Systems Biology, University
of Chicago , Chicago, Illinois 60290, USA
[26
]Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham
and Women's Hospital, Harvard Medical School , Boston, Massachusetts 02108, USA
[27
]Center of Human Development and Aging, New Jersey Medical School , Newark 07101, USA
[28
]General Internal Medicine Section, Boston University , Boston, Massachusetts 02108, USA
[29
]The Mathematical and Statistical Computing Laboratory, Center for Information Technology,
National Institutes of Health , Bethesda, Maryland 20817, USA
[30
]Department of Epidemiology, Erasmus Medical Center , Rotterdam 3000CA, The Netherlands
[31
]Molecular Pathology, Institute of Biomedicine, University of Tartu , Tartu 0794, Estonia
[32
]Department of Cardiovascular Sciences, University of Leicester , Leicester LE1, UK
[33
]National Institute for Health Research Leicester Cardiovascular Biomedical Research
Unit, Glenfield Hospital , Leicester LE1, UK
[34
]Institute of Molecular and Cell Biology, Estonian Genome Center, University of Tartu , Tartu 0794, Estonia
[35
]Institute of Epidemiologie II, Helmholtz Zentrum Muenchen, German Research Center
for Environmental Health , Neuherberg 85764, Germany
[36
]Research Unit of Molecular Epidemiology, Helmholtz Zentrum Muenchen, German Research
Center for Environmental Health , Neuherberg 85764, Germany
[37
]Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes
Research at Heinrich Heine University Düsseldorf , Düsseldorf 40593, Germany
[38
]Division of Endocrinology and Diabetology, University Hospital Düsseldorf, Heinrich
Heine University , Düsseldorf 40593, Germany
[39
]Hannover Unified Biobank, Hannover Medical School , Hannover 30519, Germany
[40
]Department of Psychiatry and Psychotherapy, Helios Hospital Stralsund, University
Medicine Greifswald , Greifswald 17489, Germany
[41
]Institute for Community Medicine, University Medicine Greifswald , Greifswald 17489, Germany
[42
]Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology,
University Medicine Greifswald , Greifswald 17489, Germany
[43
]Genetics of Complex Traits, University of Exeter Medical School, University of Exeter , Exeter EX2 5DW, UK
[44
]Geriatric Unit, Azienda Sanitaria di Firenze , Florence 50123, Italy
[45
]Centre for Genetic Origins of Health and Disease, The University of Western Australia,
and Faculty of Health Sciences, Curtin University , Perth, Western Australia 9011, Australia
[46
]Program in Medical and Population Genetics, Broad Institute of MIT and Harvard , Cambridge 02138, USA
[47
]Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's
Hospital and Harvard Medical School , Boston, Massachusetts 02108, USA
[48
]Partners Center for Personalized Genetic Medicine , Boston, Massachusetts 02108, USA
[49
]The Queensland Brain Institute, University of Queensland , Brisbane, Queensland 4000, Australia
[50
]University of Queensland Diamantina Institute, University of Queensland, Princess
Alexandra Hospital , Brisbane, Queensland 4000, Australia
[51
]Department of Epidemiology, University of Michigan , Ann Arbor, Michigan 48103, USA
[52
]Department of Biosciences, University of Helsinki , Helsinki 00100, Finland
[53
]Department of Mental Health and Substance Abuse Services, National Institute for Health
and Welfare , Helsinki 00100, Finland
[54
]Wellcome Trust Sanger Institute , Hinxton, Cambridge CB4, UK
[55
]Department of Public Health, Hjelt Institute, University of Helsinki , Helsinki 00100, Finland
[56
]QIMR Berghofer Medical Research Institute , Brisbane, Queensland 4000, Australia
[57
]Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine , Atlanta, Georgia 30301, USA
[58
]Max-Planck Institute of Psychiatry , Munich 80331, Germany
[59
]Department of Internal Medicine, Wake Forest School of Medicine , Winston-Salem, North Carolina 27101, USA
[60
]Department of Epidemiology, University of Washington , Seattle, Washington 98101, USA
[61
]Cardiovascular Health Research Unit, Department of Medicine, University of Washington , Seattle, Washington 98101, USA
[62
]Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical
Research Institute at Harbor-UCLA Medical Center , Torrance, California 90501, USA
[63
]Department of Medical Statistics, Leiden University Medical Center , Leiden 2300RC, The Netherlands
[64
]Department of Rheumatology, Leiden University Medical Center , Leiden 2300RC, The Netherlands
[65
]Department of Clinical Epidemiology, Leiden University Medical Center , Leiden 2300RC, The Netherlands
[66
]Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical
School , Boston, Massachusetts 02138, USA
[67
]Cardiovascular Health Research Unit, Department of Medicine, University of Washington , Seattle, Washington 98195, USA
[68
]Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington , Seattle, Washington 98195, USA
[69
]Cardiovascular Health Research Unit, Department of Health Services, University of
Washington , Seattle, Washington 98195, USA
[70
]Group Health Research Institute, Group Health Cooperative , Seattle, Washington 98195, USA
[71
]Department of Pathology, University of Vermont College of Medicine , Colchester, Vermont 98195, USA
[72
]Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic , Rochester, Minnesota 55901, USA
[73
]Computational Medicine, Institute of Health Sciences, Faculty of Medicine, University
of Oulu , Oulu 90570, Finland
[74
]Clinical Research Branch, National Institute on Aging , Baltimore, Maryland 21218, USA
[75
]Division of Endocrinology, Children's Hospital Boston , Boston, Massachusetts 02108, USA
[76
]Department of Genetics, Harvard Medical School , Boston, Massachusetts 02108, USA
[77
]Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health , Bethesda, Maryland 20817, USA.
[78
]Reta Lila Weston Institute and Department of Molecular Neuroscience, UCL Institute
of Neurology , Queen Square, London WC1N 3BG, UK.
[79
]Department of Medical and Molecular Genetics, King's College London, Guy's Hospital , London SE1 9RT, UK.
[80
]Research Resources Branch, National Institute on Aging, National Institutes of Health,
Bethesda , Maryland 20817, USA.
[81
]Department of Neuroscience, Karolinska Institutet , Stockholm 10044, Sweden.
[82
]Department of Neuropathology, MRC Sudden Death Brain Bank Project, University of Edinburgh , Edinburgh EH13, UK.
[83
]Lymphocyte Cell Biology Unit, Laboratory of Immunology, National Institute on Aging,
National Institutes of Health , Baltimore, Maryland 20817, USA.
[84
]Department of Genetics, King Faisal Specialist Hospital and Research Centre 11564, Saudi Arabia.
[85
]Brain Resource Center, Johns Hopkins University , Baltimore, Maryland 20817, USA.
[86
]ITGR Biomarker Discovery Group, Genentech , South San Francisco, California 94101, USA.
[87
]NICHD Brain and Tissue Bank for Developmental Disorders, University of Maryland Medical
School , Baltimore, Maryland 2117, USA.
Ageing increases the risk of many diseases. Here the authors compare blood cell transcriptomes
of over 14,000 individuals and identify a set of about 1,500 genes that are differently
expressed with age, shedding light on transcriptional programs linked to the ageing
process and age-associated diseases.
