There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Ibuprofen, a nonsteroidal anti-inflammatory agent, was studied in the early stages
of myocardial ischemia in order to determine whether it helps preserve myocardial
integrity. Ibuprofen was administered intravenously at a dose of 12.5 mg/kg at the
time of coronary artery occlusion and again 2.5 h later. Ibuprofen significantly prevented
the loss of myocardial creatine phosphokinase (CPK) release in ischemic cardiac tissue.
In addition, this drug significantly returned S-T segment elevation toward normal
values, and significantly prevented the myocardial loss of compounds having free amino
nitrogen groups, an index of proteolysis. Although ibuprofen moderated the increased
plasma CPK activity, plasma CPK values 5 h after coronary occlusion were above control
values. Thus, ibuprofen significantly prevented alterations in three of the four indices
used to assess myocardial ischemic damage. The protective mechanism of ibuprofen may
be via stabilization of cellular membranes (i.e., lysosomal membranes) and to a lesser
extent on reduction in myocardial oxygen demand.