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      Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome: Nothing New Under the Sun.

      1 , 2

      Immunology and allergy clinics of North America

      Elsevier BV

      ACOS, Asthma, COPD, Overlap, Subtypes

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          Abstract

          The debate about whether asthma and chronic obstructive pulmonary disease (COPD) are distinct clinical syndromes is not new; there is heightened interest in understanding the group of individuals with obstructive lung disease who seem to have elements of both conditions because recent studies have demonstrated increased risk for respiratory events and exacerbations. We describe the clinical characteristics of this subtype of disease and suggest 4 working definitions of individuals who would fall into the asthma-COPD overlap category. Understanding the mechanisms underlying these subtypes will hopefully lead into a better understanding of therapeutic strategies that can target specific pathobiologic pathways.

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          Author and article information

          Journal
          Immunol Allergy Clin North Am
          Immunology and allergy clinics of North America
          Elsevier BV
          1557-8607
          0889-8561
          August 2016
          : 36
          : 3
          Affiliations
          [1 ] Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, JHAAC 4B.74, Baltimore, MD 21224, USA. Electronic address: Nputcha1@jhmi.edu.
          [2 ] Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, JHAAC 4B.74, Baltimore, MD 21224, USA.
          Article
          S0889-8561(16)30003-0 NIHMS792128
          10.1016/j.iac.2016.03.003
          4943670
          27401623
          Copyright © 2016 Elsevier Inc. All rights reserved.

          ACOS, Asthma, COPD, Overlap, Subtypes

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