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      Journal of Pain Research (submit here)

      This international, peer-reviewed Open Access journal by Dove Medical Press focuses on reporting of high-quality laboratory and clinical findings in all fields of pain research and the prevention and management of pain. Sign up for email alerts here.

      52,235 Monthly downloads/views I 2.832 Impact Factor I 4.5 CiteScore I 1.2 Source Normalized Impact per Paper (SNIP) I 0.655 Scimago Journal & Country Rank (SJR)

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      The safety of liposome bupivacaine following various routes of administration in animals.

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          Abstract

          This report presents results from four preclinical studies evaluating safety and pharmacokinetics (PKs) of liposome bupivacaine following intravascular (intravenous [IV], intra-arterial [IA]), epidural, and intrathecal administration in dogs.

          Most cited references22

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          ASRA practice advisory on local anesthetic systemic toxicity.

          Joseph Neal, Christopher Bernards, John F Butterworth … (2024)
          The American Society of Regional Anesthesia and Pain Medicine Practice Advisory on Local Anesthetic Systemic Toxicity assimilates and summarizes current knowledge regarding the prevention, diagnosis, and treatment of this potentially fatal complication. It offers evidence-based and/or expert opinion-based recommendations for all physicians and advanced practitioners who routinely administer local anesthetics in potentially toxic doses. The advisory does not address issues related to local anesthetic-related neurotoxicity, allergy, or methemoglobinemia. Recommendations are based primarily on animal and human experimental trials, case series, and case reports. When objective evidence is lacking or incomplete, recommendations are supplemented by expert opinion from the Practice Advisory Panel plus input from other experts, medical specialty groups, and open forum. Specific recommendations are offered for the prevention, diagnosis, and treatment of local anesthetic systemic toxicity.
          Article 0 comments Cited 89 times – based on 0 reviews     Review now
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            The role of the anesthesiologist in fast-track surgery: from multimodal analgesia to perioperative medical care.

            Scott J Neal, Thomas Schricker, Franco Carli … (2007)
            Improving perioperative efficiency and throughput has become increasingly important in the modern practice of anesthesiology. Fast-track surgery represents a multidisciplinary approach to improving perioperative efficiency by facilitating recovery after both minor (i.e., outpatient) and major (inpatient) surgery procedures. In this article we focus on the expanding role of the anesthesiologist in fast-track surgery. A multidisciplinary group of clinical investigators met at McGill University in the Fall of 2005 to discuss current anesthetic and surgical practices directed at improving the postoperative recovery process. A subgroup of the attendees at this conference was assigned the task of reviewing the peer-reviewed literature on this topic as it related to the role of the anesthesiologist as a perioperative physician. Anesthesiologists as perioperative physicians play a key role in fast-track surgery through their choice of preoperative medication, anesthetics and techniques, use of prophylactic drugs to minimize side effects (e.g., pain, nausea and vomiting, dizziness), as well as the administration of adjunctive drugs to maintain major organ system function during and after surgery. The decisions of the anesthesiologist as a key perioperative physician are of critical importance to the surgical care team in developing a successful fast-track surgery program.
            Article 0 comments Cited 64 times – based on 0 reviews     Review now
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              Procedure-specific pain management and outcome strategies.

              Girish Joshi, Stephan Schug, Henrik Kehlet (2014)
              Optimal dynamic pain relief is a prerequisite for optimizing post-operative recovery and reducing morbidity and convalescence. Procedure-specific pain management initiative aims to overcome the limitations of conventional guidelines and provide health-care professionals with practical recommendations formulated in a way that facilitates clinical decision making across all the stages of the perioperative period. The procedure-specific evidence is supplemented with data from other similar surgical procedures and clinical practices to balance benefits and risks of each analgesic technique. There is emphasis on the use of multimodal analgesia and preventive analgesia aimed at reducing central sensitization. Importantly, the benefits of dynamic pain relief may only be realized if other aspects of perioperative care such as the use of minimally invasive surgery, approaches to reduce stress responses, optimizing fluid therapy and optimizing post-operative nursing care with early mobilization and oral feeding are utilized.
              Article 0 comments Cited 44 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (iso-abbrev): J Pain Res
                Title: Journal of pain research
                Publisher: Informa UK Limited
                ISSN: 1178-7090
                ISSN (Print): 1178-7090
                Publication date (Electronic): 2015
                Volume: 8
                Affiliations
                [1 ] Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical School, Dallas, TX, USA.
                [2 ] Pacira Pharmaceuticals, Inc., Parsippany, NJ, USA.
                Article
                Publisher Item ID: jpr-8-781
                DOI: 10.2147/JPR.S85424
                PMC ID: 4634838
                PubMed ID: 26586964
                SO-VID: 1655cd7d-9875-4c6e-b966-832bc2cd3ab4
                History

                Keywords: local anesthesia,bupivacaine,drug administration routes,spinal injections
                Data availability:
                Keywords: local anesthesia, bupivacaine, drug administration routes, spinal injections

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