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      Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia.

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          Abstract

          A previously unknown coronavirus was isolated from the sputum of a 60-year-old man who presented with acute pneumonia and subsequent renal failure with a fatal outcome in Saudi Arabia. The virus (called HCoV-EMC) replicated readily in cell culture, producing cytopathic effects of rounding, detachment, and syncytium formation. The virus represents a novel betacoronavirus species. The closest known relatives are bat coronaviruses HKU4 and HKU5. Here, the clinical data, virus isolation, and molecular identification are presented. The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.

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          Author and article information

          Journal
          N Engl J Med
          The New England journal of medicine
          Massachusetts Medical Society
          1533-4406
          0028-4793
          Nov 08 2012
          : 367
          : 19
          Affiliations
          [1 ] Dr Soliman Fakeeh Hospital, Jeddah, Saudi Arabia.
          Article
          10.1056/NEJMoa1211721
          23075143
          0fa6fe47-cec9-4e02-9621-86cd3e49bcc6
          History

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