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      Cross-calibration, Least Significant Change and Quality Assurance in Multiple Dual-Energy X-ray Absorptiometry Scanner Environments: 2019 ISCD Official Position.

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          In preparation for the International Society for Clinical Densitometry Position Development Conference (PDC) 2019 in Kuala Lumpur, Malaysia, a cross-calibration and precision task force was assembled and tasked to review the literature, summarize the findings, and generate positions to answer 4 related questions provided by the PDC Steering Committee, which expand upon the current ISCD official positions on these subjects. (1) How should a provider with multiple dual-energy X-ray absorptiometry (DXA) scanners of the same make and model calculate least significant change (LSC)? (2) How should a provider with multiple DXA systems with the same manufacturer but different models calculate LSC? (3) How should a provider with multiple DXA systems from different manufacturers and models calculate LSC? (4) Are there specific phantom procedures that one can use to provide trustworthy in vitro cross calibration for same models, different models, and different makes? Based on task force deliberations and the resulting systematic literature reviews, 3 new positions were developed to address these more complex scenarios not addressed by current official positions on single scanner cross calibration and LSC. These new positions provide appropriate guidance to large multiple DXA scanner providers wishing to offer patients flexibility and convenience, and clearly define good clinical practice requirements to that end.

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          Author and article information

          J Clin Densitom
          Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
          Elsevier BV
          September 29 2019
          : 22
          : 4
          [1 ] Bone Densitometry Lab, Illinois Bone and Joint Institute, LLC, Morton Grove, IL, USA. Electronic address: ljankowski@ibji.com.
          [2 ] Medical Imaging, Paraxel International, Waltham MA, USA.
          [3 ] Medical Imaging, Bioclinica, Newark, CA, USA.
          [4 ] Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
          [5 ] Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
          [6 ] Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA, USA.
          [7 ] Population Sciences in the Pacific, University of Hawaii Cancer Center, Honolulu, HI, USA.

          precision,official positions,least significant change,cross calibration,Dual-energy X-ray absorptiometry


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