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      • Record: found
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      • Article: found

      Clinical analysis of benign eyelid and conjunctival tumors.

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      Publication date:
      Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
      Keywords: Adult, Biopsy, Conjunctiva, pathology, Conjunctival Neoplasms, epidemiology, Diagnosis, Differential, Eyelid Neoplasms, Eyelids, Female, Humans, Keratosis, Seborrheic, Male, Middle Aged, Nevus, Intradermal, Prevalence, Retrospective Studies, Skin Neoplasms

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          Abstract

          To assess the relative frequency and clinicopathologic characteristics of benign conjunctival tumors. A retrospective study of 80 consecutive patients admitted to our hospital with benign eyelid and conjunctival tumor between April 2000 and November 2002 was undertaken, and clinical records including age, sex and involved site of tumors and pathology slides of the patients were reviewed retrospectively. Twenty-three males and 33 females presented with benign eyelid tumors and 12 males and 12 females with conjunctival tumors. Mean age was 42.3 and 29.7 years, respectively. The lower eyelid was involved in 27 (48.2%) of eyelid tumors and the medial conjunctiva in 14 (58.3%) of conjunctival tumors. The most frequent tumor was intradermal nevus (44.6%), seborrheic keratosis (16.1%) and compound nevus (10.7%) in eyelid tumors, and compound nevus (29.2%) and intradermal nevus (25.0%) in conjunctival tumors. This report will provides a basic analysis of benign eyelid and conjunctival tumors. 2006 S. Karger AG, Basel

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          Pyogenic granuloma (lobular capillary hemangioma): a clinicopathologic study of 178 cases.

          J Mulliken, K Wiss, J Patrice (1991)
          Pyogenic granuloma (lobular capillary hemangioma) is a common acquired vascular lesion of the skin and mucous membranes in the pediatric age group. This is a retrospective analysis of 178 patients, 17 years of age and younger (mean age 6.7 yrs). Forty-two percent of the lesions occurred in the first five years of life; only 12% appeared in infants less than 1 year old. The male:female ratio was 3:2. Most patients (74.2%) had no history of trauma or predisposing dermatologic condition. The mean lesional size was 6.5 mm and the mean duration at diagnosis was 3.8 months. The granulomas were most commonly located in the head and neck area (62.4%), followed in order of decreasing frequency by trunk (19.7%), upper extremity (12.9%), and lower extremity (5.0%). The preponderance (88.2%) occurred on the skin, the remaining ones involved the mucous membranes of the oral cavity and conjunctivae. Histologic examination demonstrated normal numbers of mast cells, in contrast to increased mast cells characteristic of proliferative phase hemangiomas. Most lesions (n = 149) were treated by full-thickness skin excision and linear closure; there were no recurrences in this group. The recurrence rate in 23 lesions treated by shave (intradermal) excision and cautery or cautery alone was 43.5%.
          Article 0 comments Cited 47 times – based on 0 reviews     Review now
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            A clinical review of 209 pilomatricomas.

            Celia G. Julian, P.W. Bowers (1998)
            Pilomatricomas have a wide variety of clinical characteristics and are often misdiagnosed. This can result in extensive surgery for an essentially benign condition. The purpose of this study was to define the clinical and histologic spectrum of these tumors to aid diagnosis. Two hundred nine cases were analyzed retrospectively with regard to age at presentation, site, size, and physical appearance. Pilomatricomas appear at any age, with peak presentation bimodally in the first and sixth decade. Their most common site is the head and neck. Presentation is of a hard nodule, either deeply subcutaneous and invisible or superficial with possible erosion through the skin surface. This may lead to a false diagnosis of malignancy or of an epidermoid cyst. An association with myotonic dystrophy has been confirmed, as is the rare occurrence of malignant transformation. Careful clinical examination and a high index of suspicion results in an accurate diagnosis, appropriate treatment, and the avoidance of unnecessarily extensive surgery.
            Article 0 comments Cited 40 times – based on 0 reviews     Review now
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              Human papillomavirus and human disease.

              Karl R Beutner, MD, PhD, Stephen Tyring, MD, PhD (1997)
              Human papillomaviruses (HPVs) are associated with a spectrum of different diseases in humans, including common warts and genital warts. Of more serious concern is the connection between certain HPV types and some malignancies, particularly cervical and anal cancer. DNA from HPV-16 and HPV-18, two types frequently found in cervical cancer tissue, can immortalize cells in laboratory cultures, unlike DNA from HPV types associated with benign genital lesions. Although it is unclear how high-risk HPV types cause cancer, studies indicate that malignant transformation involves the viral E6 and E7 gene products, which may exert their effect by interfering with the cellular proteins that regulate cell growth. The vast majority of those infected do not develop malignancies, indicating that HPV infection alone is not enough to cause cancer. Cofactors such as cigarette smoking, may be required before neoplasia can occur. The potential seriousness of HPV infections is suggested by the observations that the number of genital HPV infections diagnosed is increasing and that cervical cancer is the second leading cause of cancer deaths in women throughout the world.
              Article 0 comments Cited 18 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                PubMed ID:: 16374048
                DOI:: 10.1159/000089274

                ScienceOpen disciplines: Chemistry
                Keywords: Adult,Biopsy,Conjunctiva,pathology,Conjunctival Neoplasms,epidemiology,Diagnosis, Differential,Eyelid Neoplasms,Eyelids,Female,Humans,Keratosis, Seborrheic,Male,Middle Aged,Nevus, Intradermal,Prevalence,Retrospective Studies,Skin Neoplasms
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                ScienceOpen disciplines: Chemistry
                Keywords: Adult, Biopsy, Conjunctiva, pathology, Conjunctival Neoplasms, epidemiology, Diagnosis, Differential, Eyelid Neoplasms, Eyelids, Female, Humans, Keratosis, Seborrheic, Male, Middle Aged, Nevus, Intradermal, Prevalence, Retrospective Studies, Skin Neoplasms

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