59
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      P2X receptors as cell-surface ATP sensors in health and disease.

      Nature
      Adenosine Triphosphate, analysis, metabolism, Cell Membrane, Disease, Health, Humans, Inflammation, Pain, pathology, Receptors, Purinergic P2, chemistry, Receptors, Purinergic P2X

      Read this article at

      ScienceOpenPublisherPubMed
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          P2X receptors are membrane ion channels activated by the binding of extracellular adenosine triphosphate (ATP). For years their functional significance was consigned to distant regions of the autonomic nervous system, but recent work indicates several further key roles, such as afferent signalling, chronic pain, and in autocrine loops of endothelial and epithelial cells. P2X receptors have a molecular architecture distinct from other ion channel protein families, and have several unique functional properties.

          Related collections

          Author and article information

          Comments

          Comment on this article