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Community-associated meticillin-resistant Staphylococcus aureus
May 2010
May 2010
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Abstract
Meticillin-resistant Staphylococcus aureus (MRSA) is endemic in hospitals worldwide,
and causes substantial morbidity and mortality. Health-care-associated MRSA infections
arise in individuals with predisposing risk factors, such as surgery or presence of
an indwelling medical device. By contrast, many community-associated MRSA (CA-MRSA)
infections arise in otherwise healthy individuals who do not have such risk factors.
Additionally, CA-MRSA infections are epidemic in some countries. These features suggest
that CA-MRSA strains are more virulent and transmissible than are traditional hospital-associated
MRSA strains. The restricted treatment options for CA-MRSA infections compound the
effect of enhanced virulence and transmission. Although progress has been made towards
understanding emergence of CA-MRSA, virulence, and treatment of infections, our knowledge
remains incomplete. Here we review the most up-to-date knowledge and provide a perspective
for the future prophylaxis or new treatments for CA-MRSA infections.
Copyright 2010 Elsevier Ltd. All rights reserved.