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      CalR: A Web-Based Analysis Tool for Indirect Calorimetry Experiments.

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          Abstract

          We report a web-based tool for analysis of experiments using indirect calorimetry to measure physiological energy balance. CalR simplifies the process to import raw data files, generate plots, and determine the most appropriate statistical tests for interpretation. Analysis using the generalized linear model (which includes ANOVA and ANCOVA) allows for flexibility in interpreting diverse experimental designs, including those of obesity and thermogenesis. Users also may produce standardized output files for an experiment that can be shared and subsequently re-evaluated using CalR. This framework will provide the transparency necessary to enhance consistency, rigor, and reproducibility. The CalR analysis software will greatly increase the speed and efficiency with which metabolic experiments can be organized, analyzed per accepted norms, and reproduced and will likely become a standard tool for the field. CalR is accessible at https://CalRapp.org/.

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          Author and article information

          Journal
          Cell Metab
          Cell metabolism
          Elsevier BV
          1932-7420
          1550-4131
          October 02 2018
          : 28
          : 4
          Affiliations
          [1 ] Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.
          [2 ] Springbok LLC, Boston, MA 02109, USA.
          [3 ] Division of Gastroenterology & Hepatology, Weill Cornell Medical College, New York, NY 10065, USA.
          [4 ] Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37212, USA.
          [5 ] Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA. Electronic address: abanks@bwh.harvard.edu.
          Article
          S1550-4131(18)30401-7 NIHMS978362
          10.1016/j.cmet.2018.06.019
          6170709
          30017358
          ca922f38-e6c7-4e42-8846-e57e232b47b9
          Copyright © 2018 Elsevier Inc. All rights reserved.
          History

          ANCOVA,CLAMS,biostatistics,energy balance,energy expenditure,food intake,indirect calorimetry,metabolic phenotyping,metabolism,reproducibility

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