There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

The complement system functions as an immune surveillance system that rapidly responds to infection. Activation of the complement system by specific recognition pathways triggers a protease cascade, generating cleavage products that function to eliminate pathogens, regulate inflammatory responses, and shape adaptive immune responses. However, when dysregulated, these powerful functions can become destructive and the complement system has been implicated as a pathogenic effector in numerous diseases, including infectious diseases. This review highlights recent discoveries that have identified critical roles for the complement system in the pathogenesis of viral infection. Copyright © 2010 Elsevier Inc. All rights reserved.

Related collections

Most cited references 122

Record: found
Abstract: found
Article: found

Global Spread and Persistence of Dengue

Jennifer L. Kyle, Eva Harris (2008)

Dengue is a spectrum of disease caused by four serotypes of the most prevalent arthropod-borne virus affecting humans today, and its incidence has increased dramatically in the past 50 years. Due in part to population growth and uncontrolled urbanization in tropical and subtropical countries, breeding sites for the mosquitoes that transmit dengue virus have proliferated, and successful vector control has proven problematic. Dengue viruses have evolved rapidly as they have spread worldwide, and genotypes associated with increased virulence have expanded from South and Southeast Asia into the Pacific and the Americas. This review explores the human, mosquito, and viral factors that contribute to the global spread and persistence of dengue, as well as the interaction between the three spheres, in the context of ecological and climate changes. What is known, as well as gaps in knowledge, is emphasized in light of future prospects for control and prevention of this pandemic disease.

0 comments Cited 276 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever.

Daniel H. Libraty, Paul R Young, Darren Pickering … (2002)

Infection with any 1 of 4 dengue viruses produces a spectrum of clinical illness ranging from a mild undifferentiated febrile illness to dengue fever (DF) to dengue hemorrhagic fever (DHF), a potentially life-threatening disease. The morbidity and mortality of DHF can be reduced by early hospitalization and careful supportive care. To determine its usefulness as a predictor of DHF, plasma levels of the secreted dengue virus nonstructural protein NS1 (sNS1) were measured daily in 32 children with dengue-2 virus infections participating in a prospective, hospital-based study. Free sNS1 levels in plasma correlated with viremia levels and were higher in patients with DHF than in those with DF. An elevated free sNS1 level (> or =600 ng/mL) within 72 h of illness onset identified patients at risk for developing DHF.

0 comments Cited 205 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Complement and coagulation: strangers or partners in crime?

Maciej Markiewski, Bo Nilsson, Kristina Nilsson Ekdahl … (2007)

The convergence between complement and the clotting system extends far beyond the chemical nature of the complement and coagulation components, both of which form proteolytic cascades. Complement effectors directly enhance coagulation. These effects are supplemented by the interactions of complement with other inflammatory mediators that can increase the thrombogenicity of blood. In addition, complement inhibits anticoagulant factors. The crosstalk between complement and coagulation is also well illustrated by the ability of certain coagulation enzymes to activate complement components. Understanding the interplay between complement and coagulation has fundamental clinical implications in the context of diseases with an inflammatory pathogenesis, in which complement-coagulation interactions contribute to the development of life-threatening complications. Here, we review the interactions of the complement system with hemostasis and their roles in various diseases.

0 comments Cited 173 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

PubMed ID:: 21292294

PMC ID:: 3073741

DOI:: 10.1016/j.virol.2010.12.045

ScienceOpen disciplines: Chemistry

Keywords: Complement System Proteins,immunology,toxicity,Humans,Virus Diseases,pathology,Viruses,pathogenicity

Data availability:

ScienceOpen disciplines: Chemistry

Keywords: Complement System Proteins, immunology, toxicity, Humans, Virus Diseases, pathology, Viruses, pathogenicity

Complement and viral pathogenesis.

Read this article at

Abstract

Related collections

GLUT4 biology

Most cited references 122

Global Spread and Persistence of Dengue

High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever.

Complement and coagulation: strangers or partners in crime?

Author and article information

Journal

Comments

Comment on this article

Similar content 88

Cited by 111

Most referenced authors 2,103