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      Subjective symptoms related to GSM radiation from mobile phone base stations: a cross-sectional study.

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          Abstract

          We performed a re-analysis of the data from Navarro et al (2003) in which health symptoms related to microwave exposure from mobile phone base stations (BSs) were explored, including data obtained in a retrospective inquiry about fear of exposure from BSs.

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          Most cited references24

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          Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects

          The direct targets of extremely low and microwave frequency range electromagnetic fields (EMFs) in producing non-thermal effects have not been clearly established. However, studies in the literature, reviewed here, provide substantial support for such direct targets. Twenty-three studies have shown that voltage-gated calcium channels (VGCCs) produce these and other EMF effects, such that the L-type or other VGCC blockers block or greatly lower diverse EMF effects. Furthermore, the voltage-gated properties of these channels may provide biophysically plausible mechanisms for EMF biological effects. Downstream responses of such EMF exposures may be mediated through Ca2+/calmodulin stimulation of nitric oxide synthesis. Potentially, physiological/therapeutic responses may be largely as a result of nitric oxide-cGMP-protein kinase G pathway stimulation. A well-studied example of such an apparent therapeutic response, EMF stimulation of bone growth, appears to work along this pathway. However, pathophysiological responses to EMFs may be as a result of nitric oxide-peroxynitrite-oxidative stress pathway of action. A single such well-documented example, EMF induction of DNA single-strand breaks in cells, as measured by alkaline comet assays, is reviewed here. Such single-strand breaks are known to be produced through the action of this pathway. Data on the mechanism of EMF induction of such breaks are limited; what data are available support this proposed mechanism. Other Ca2+-mediated regulatory changes, independent of nitric oxide, may also have roles. This article reviews, then, a substantially supported set of targets, VGCCs, whose stimulation produces non-thermal EMF responses by humans/higher animals with downstream effects involving Ca2+/calmodulin-dependent nitric oxide increases, which may explain therapeutic and pathophysiological effects.
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            Inflation of the type I error rate when a continuous confounding variable is categorized in logistic regression analyses.

            This paper demonstrates an inflation of the type I error rate that occurs when testing the statistical significance of a continuous risk factor after adjusting for a correlated continuous confounding variable that has been divided into a categorical variable. We used Monte Carlo simulation methods to assess the inflation of the type I error rate when testing the statistical significance of a risk factor after adjusting for a continuous confounding variable that has been divided into categories. We found that the inflation of the type I error rate increases with increasing sample size, as the correlation between the risk factor and the confounding variable increases, and with a decrease in the number of categories into which the confounder is divided. Even when the confounder is divided in a five-level categorical variable, the inflation of the type I error rate remained high when both the sample size and the correlation between the risk factor and the confounder were high. Copyright 2004 John Wiley & Sons, Ltd.
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              Subjective symptoms, sleeping problems, and cognitive performance in subjects living near mobile phone base stations.

              The erection of mobile telephone base stations in inhabited areas has raised concerns about possible health effects caused by emitted microwaves. In a cross-sectional study of randomly selected inhabitants living in urban and rural areas for more than one year near to 10 selected base stations, 365 subjects were investigated. Several cognitive tests were performed, and wellbeing and sleep quality were assessed. Field strength of high-frequency electromagnetic fields (HF-EMF) was measured in the bedrooms of 336 households. Total HF-EMF and exposure related to mobile telecommunication were far below recommended levels (max. 4.1 mW/m2). Distance from antennae was 24-600 m in the rural area and 20-250 m in the urban area. Average power density was slightly higher in the rural area (0.05 mW/m2) than in the urban area (0.02 mW/m2). Despite the influence of confounding variables, including fear of adverse effects from exposure to HF-EMF from the base station, there was a significant relation of some symptoms to measured power density; this was highest for headaches. Perceptual speed increased, while accuracy decreased insignificantly with increasing exposure levels. There was no significant effect on sleep quality. Despite very low exposure to HF-EMF, effects on wellbeing and performance cannot be ruled out, as shown by recently obtained experimental results; however, mechanisms of action at these low levels are unknown.
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                Author and article information

                Journal
                BMJ Open
                BMJ open
                BMJ
                2044-6055
                2044-6055
                Dec 30 2013
                : 3
                : 12
                Affiliations
                [1 ] Research Center, University Hospital La Fe, Valencia, Spain.
                Article
                bmjopen-2013-003836
                10.1136/bmjopen-2013-003836
                3885815
                24381254
                b022bb6f-7d1c-4fe6-9591-8b6670090b01
                History

                Epidemiology,Occupational & Industrial Medicine,Public Health

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