About Blood Purification:3.0 Impact Factor I 5.6 CiteScore I 0.83 Scimago Journal & Country Rank (SJR)
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Inhibition of the Accumulation of Uremic Toxins in the Blood and Their Precursors in the Feces after Oral Administration of Lebenin®, a Lactic Acid Bacteria Preparation, to Uremic Patients Undergoing Hemodialysis
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Abstract
The plasma levels of phenol, p -creso l, and indican are markedly increased in uremic
patients, and cannot be efficiently reduced by hemodialysis. Such uremic toxins, which
are produced in the intestine as bacterial putrefactive metabolites, accumulate to
a great degree in the feces of hemodialysis patients. Oral administration of Lebenin®,
a preparation consisting of antibiotic-resistant lactic acid bacteria, reduced the
levels of fecal putrefactive metabolites to levels comparable with those of healthy
subjects. Moreover, the plasma level of indican also significantly decreased in these
Lebenin-treated patients. An analysis of the fecal microflora revealed that a disturbed
composition of the microflora characterized by an overgrowth of aerobic bacteria is
restored to normal by oral administration of Lebenin in hemodialysis patients. These
results thus demonstate that oral administration of lactic acid bacteria in uremic
patients is effective in reducing the levels of uremic toxins, especially that of
indican, in the blood by inhibiting bacterial production by means of correcting the
intestinal microflora.