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      Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

      Nature biotechnology

      Springer Nature

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          NIH Image to ImageJ: 25 years of image analysis.

          For the past 25 years NIH Image and ImageJ software have been pioneers as open tools for the analysis of scientific images. We discuss the origins, challenges and solutions of these two programs, and how their history can serve to advise and inform other software projects.
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            2012. NIH Image to ImageJ: 25 years of image analysis

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              CRISPR RNA-guided activation of endogenous human genes

              Catalytically inactive CRISPR-associated 9 nuclease (dCas9) can be directed by short guide RNAs (gRNAs) to repress endogenous genes in bacteria and human cells. Here we show that a dCas9-VP64 transcriptional activation domain fusion protein can be directed by single or multiple gRNAs to increase expression of specific endogenous human genes. These results provide an important proof-of-principle that CRISPR-Cas systems can be used to target heterologous effector domains in human cells.
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                Author and article information

                Journal
                10.1038/nbt.3081

                http://www.springer.com/tdm

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