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Abstract
This brief review summarizes the author’s current understanding of the circulatory
changes in hypertension. Differences in four important regulatory systems are dependent
on structural changes: (1) An increase in wall-to-lumen ratio of precapillary resistance
vessels is responsible for an increase in vascular reactivity, or ‘structural autoregulation’.
(2) A structural change primarily in the preglomerular arteriole causes a resetting
of the pressure required for glomerular filtration. This serves a ‘long-tem barostatic
function’. (3) Stiffening of the aorta and other pressure-sensing systems contributes
to a resetting of baroreceptors bringing about a reset of the ‘short-term barostats’.
(4) Left ventricular hypertrophy causes a decrease in compliance, hence tending to
decrease stroke volume for a given filling pressure. Functional changes such as increased
neurogenic activity may serve as important ‘trigger’ elements in spontaneously hypertensive
rats and at least in one important variant of essential hypertension in the human.
An example of a functional alteration in vascular smooth muscle is found in that the
vascular resistance response in the spontaneously hypertensive rat in low calcium
concentration (0.2 mM) is better maintained than in the normotensive control rat,
but this alteration seems to be secondary in nature. An experiment is described which
permits simultaneous assessment of the responses of capacitance and resistance vessels
to nerve stimulation: when the splanchnic nerves are stimulated there is a simultaneous
decrease in venous capacity and an increase in resistance in the liver, gastrointestinal
tract and kidneys. The decrease in venous capacity is reflected in an increase in
stroke volume whereas the increase in regional resistance is evidenced in an incraese
in total peripheral resistance. Using this index the spontaneously hypertensive rats
had a less efficient capacitance response (possibly due to the decrease in ventricular
compliance) and a greater resistance response than did the normotensive control rat.
Although both functional and structural changes in the cardiovascular system occur,
the rapidly developed structural changes appear to be the major determinant of the
differences between normal and hypertensive hemodynamics.