Prefrontal serotonin transporter availability is positively associated with the cortisol awakening response.

Frokjaer, Vibe Gedsoe; Erritzoe, David; Holst, Klaus Kähler; Jensen, Peter Steen; Rasmussen, Peter Mondrup; Fisher, Patrick MacDonald; Baaré, William F.C.; Madsen, Kathrine Skak; Madsen, Jacob; Svarer, Claus; Knudsen, Gitte Moos

doi:10.1016/j.euroneuro.2012.05.013

Record: found
Abstract: found
Article: not found

Prefrontal serotonin transporter availability is positively associated with the cortisol awakening response.

Author(s): Vibe Gedsoe Frokjaer, David Erritzoe, Klaus Kähler Holst, Peter Jensen, Peter Rasmussen, Patrick MacDonald Fisher, William Baaré, Kathrine Madsen, Jacob Madsen, Claus Svarer, Gitte Knudsen

Publication date: 2013-04-01

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

Publisher: Elsevier BV

Read this article at

ScienceOpenPublisher PubMed

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Stress sensitivity and serotonergic neurotransmission interact, e.g. individuals carrying the low-expressing variants (S and LG) of the 5-HTTLPR promoter polymorphism of the serotonin transporter (SERT) gene are at higher risk for developing mood disorders when exposed to severe stress and display higher cortisol responses when exposed to psychosocial stressors relative to high expressing 5-HTTLPR variants. However, it is not clear how the relation between SERT and cortisol output is reflected in the adult brain. We investigated the relation between cortisol response to awakening (CAR) and SERT binding in brain regions considered relevant to modify the cortisol awakening response.