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      Call for Papers: Green Renal Replacement Therapy: Caring for the Environment

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      About Blood Purification: 3.0 Impact Factor I 5.6 CiteScore I 0.83 Scimago Journal & Country Rank (SJR)

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      Safe and Effective Use of Chronic Transdermal Estradiol for Life-Threatening Uremic Bleeding in a Patient with Coronary Artery Disease

      case-report

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          Abstract

          Uremic platelet dysfunction rarely causes significant bleeding in adequately dialyzed patients. When encountered, the management is complicated by a lack of well-supported treatment modalities. Estrogen use in uremic platelet dysfunction has been described, but enthusiasm for the treatment has been dampened by the risk of thrombotic events in vasculopathic dialysis patients. We present a patient on long-term peritoneal dialysis with coronary disease who developed recurrent life-threatening bleeding episodes secondary to uremia, where treatment with transdermal estrogen was used safely and effectively for a 24-month period.

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          Risk of venous thrombosis with oral versus transdermal estrogen therapy among postmenopausal women.

          Pierre-Yves Scarabin, Valérie Olié, Marianne Canonico (2010)
          Venous thromboembolism (VTE) is a main harmful effect of oral estrogen therapy among postmenopausal women. Transdermal estrogens may be safer but early results need to be confirmed. This review provides a summary of the most recent findings regarding the VTE risk among oral versus transdermal estrogens users.
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            Bleeding and thrombotic complications of kidney disease.

            Sue Pavord, Bethan Myers (2011)
            With the rising prevalence of kidney disease, clinicians are increasingly faced with concerns about potential thrombotic and bleeding complications. Thrombotic risk, both arterial and venous, predominates with all severities of kidney disease but bleeding manifestations become an additional concern particularly with uraemia. This article reviews these contrasting problems and discusses strategies for prevention and management in the context of renal impairment, renal replacement therapy and renal transplantation.
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              Uremic bleeding: closing the circle after 30 years of controversies?

              M Noris, G. Remuzzi (1999)
              Article 0 comments Cited 20 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Nephron Extra
                Journal ID (iso-abbrev): Nephron Extra
                Journal ID (publisher-id): NNE
                Title: Nephron Extra
                Publisher: S. Karger AG (Allschwilerstrasse 10, P.O. Box · Postfach · Case postale, CH–4009, Basel, Switzerland · Schweiz · Suisse, Phone: +41 61 306 11 11, Fax: +41 61 306 12 34, karger@karger.ch )
                ISSN (Print): 1664-5529
                ISSN (Electronic): 1664-5529
                Publication date Collection: May-Aug 2014
                Publication date (Electronic): 19 August 2014
                Publication date PMC-release: 19 August 2014
                Volume: 4
                Issue: 2
                Pages: 134-137
                Affiliations
                [1] aDepartment of Internal Medicine, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, N.Y., USA
                [2] bNephrology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, N.Y., USA
                [3] cDivision of Hematology/Oncology, Department of Medicine, University of Rochester Medical Center, Rochester, N.Y., USA
                Author notes
                *John Kevin Hix, MD, Nephrology and Hypertension Unit, 370 Ridge Road East Suite L20, Rochester, NY 14621 (USA), E-Mail john.hix@ 123456rochestergeneral.org
                Article
                Publisher ID: nne-0004-0134
                DOI: 10.1159/000365480
                PMC ID: 4164069
                SO-VID: 5e815cff-b291-47a8-9eeb-529c6c40ce17
                Copyright © Copyright © 2014 by S. Karger AG, Basel
                License:

                This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.

                History
                Page count
                Tables: 1, References: 10, Pages: 4
                Categories
                Subject: Case Report

                ScienceOpen disciplines: Nephrology
                Keywords: uremic platelets,transdermal estradiol,chronic kidney disease,bleeding
                Data availability:
                ScienceOpen disciplines: Nephrology
                Keywords: uremic platelets, transdermal estradiol, chronic kidney disease, bleeding

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