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      The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.

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          Abstract

          The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of developing criteria for the symptomatic predementia phase of Alzheimer's disease (AD), referred to in this article as mild cognitive impairment due to AD. The workgroup developed the following two sets of criteria: (1) core clinical criteria that could be used by healthcare providers without access to advanced imaging techniques or cerebrospinal fluid analysis, and (2) research criteria that could be used in clinical research settings, including clinical trials. The second set of criteria incorporate the use of biomarkers based on imaging and cerebrospinal fluid measures. The final set of criteria for mild cognitive impairment due to AD has four levels of certainty, depending on the presence and nature of the biomarker findings. Considerable work is needed to validate the criteria that use biomarkers and to standardize biomarker analysis for use in community settings.

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          Author and article information

          Journal
          Alzheimers Dement
          Alzheimer's & dementia : the journal of the Alzheimer's Association
          Elsevier BV
          1552-5279
          1552-5260
          May 2011
          : 7
          : 3
          Affiliations
          [1 ] Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. malbert9@jhmi.edu
          Article
          S1552-5260(11)00104-X NIHMS363316
          10.1016/j.jalz.2011.03.008
          3312027
          21514249
          059a3e3a-b62f-4f30-be0a-798ebfbe3efa
          Copyright © 2011 The Alzheimer's Association. All rights reserved.
          History

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