A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions.

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Abstract

The purpose of the present investigation is to report on detailed complications among a much larger group of 2372 orthopaedic patients treated with stem cell injections who were followed in a treatment registry for up to nine years.

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Most cited references 22

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Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study.

C Thomas Vangsness, Jack Farr II, Joel Boyd … (2014)

There are limited treatment options for tissue restoration and the prevention of degenerative changes in the knee. Stem cells have been a focus of intense preclinical research into tissue regeneration but limited clinical investigation. In a randomized, double-blind, controlled study, the safety of the intra-articular injection of human mesenchymal stem cells into the knee, the ability of mesenchymal stem cells to promote meniscus regeneration following partial meniscectomy, and the effects of mesenchymal stem cells on osteoarthritic changes in the knee were investigated.

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The changing prevalence of comorbidity across the age spectrum.

Edward L. Spitznagel, Emma L B Barrett, Ewout W. Steyerberg … (2008)

The purpose of the research was to demonstrate that comorbid health conditions disproportionately affect elderly cancer patients. Descriptive analyses and stacked area charts were used to examine the prevalence and severity of comorbid ailments by age of 27,506 newly diagnosed patients treated at one of eight cancer centers between 1998 and 2003. Hypertension was the most common ailment in all patients, diabetes was the second most prevalent ailment in middle-aged patients, and previous solid tumor(s) were the second most prevalent ailment in patients aged 74 and older. Although the prevalence and severity of comorbid ailments including dementia and congestive heart failure increased with age, some comorbidities such as HIV/AIDS and obesity decreased. Advances in cancer interventions have increased survivorship, but the impact of the changing prevalence and severity of comorbidities at different ages has implications for targeted research into targeted clinical and psychosocial interventions.

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A call for a standard classification system for future biologic research: the rationale for new PRP nomenclature.

Kenneth Mautner, Gerard Malanga, Jay Smith … (2015)

Autologous cell therapies including platelet-rich plasma (PRP) and bone marrow concentrate (BMC) are increasingly popular options for soft tissue and joint-related diseases. Despite increased clinical application, conflicting research has been published regarding the efficacy of PRP, and few clinical publications pertaining to BMC are available. Preparations of PRP (and BMC) can vary in many areas, including platelet concentration, number of white blood cells, presence or absence of red blood cells, and activation status of the preparation. The potential effect of PRP characteristics on PRP efficacy is often not well understood by the treating clinician, and PRP characteristics, as well as the volume of PRP delivered, are unfortunately not included in the methods of many published research articles. It is essential to establish a standard reporting system for PRP that facilitates communication and the interpretation and synthesis of scientific investigations. Herein, the authors propose a new PRP classification system reflecting important PRP characteristics based on contemporary literature and recommend adoption of minimal standards for PRP reporting in scientific investigations. Widespread adoption of these recommendations will facilitate interpretation and comparison of clinical studies and promote scientifically based progress in the field of regenerative medicine.

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Author and article information

Journal

Journal ID (iso-abbrev): Int Orthop

Title: International orthopaedics

ISSN (Electronic): 1432-5195

ISSN (Print): 0341-2695

Publication date (Electronic): Aug 2016

Volume: 40

Issue: 8

Affiliations

[1 ] Centeno-Schultz Clinic, Regenerative Sciences, LLC, 403 Summit Blvd, Broomfield, CO, 80021, USA. Centenooffice@centenoschultz.com.

[2 ] Biostatistician at Boston Children's Hospital, 450 Brookline Avenue, D-155E, Boston, MA, 02215, USA.

[3 ] Department of Psychiatry, Oregon Health and Science University School of Medicine, Portland, OR, USA.

[4 ] CAPHRI School of Public Health and Primary Care, Maastricht University, Maastricht, the Netherlands.

[5 ] Mayo Clinic Rochester, 200 1st St SW, Rochester, MN, 55905, USA.

[6 ] American Musculoskeletal Wellness Institute, P.C, 6701 Democracy Boulevard Suite 300, Bethesda, Maryland, 20817, USA.

[7 ] The Centre of Ultrasound Diagnostics and Interventional Sonography, Clinical Hospital "Pheophania" of State Affairs Department, Zabolotny Street, 21, 03680, Kyiv, Ukraine.

Article

Publisher Item ID: 10.1007/s00264-016-3162-y

DOI: 10.1007/s00264-016-3162-y

PubMed ID: 27026621

SO-VID: ed4a9a44-879f-4079-bafa-262ff0058507

History

Keywords: Bone marrow concentrate,Complications,Mesenchymal stem cells,Platelet rich plasma,Registry,Side effects

Data availability:

Keywords: Bone marrow concentrate, Complications, Mesenchymal stem cells, Platelet rich plasma, Registry, Side effects

A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions.

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Abstract

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Research from Ukraine

Most cited references 22

Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study.

The changing prevalence of comorbidity across the age spectrum.

A call for a standard classification system for future biologic research: the rationale for new PRP nomenclature.

Author and article information

Journal

Affiliations

Article

History

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