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      Association of copeptin, a surrogate marker of arginine vasopressin, with decreased kidney function in sugarcane workers in Guatemala

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          Abstract

          Background:

          Vasopressin is elevated in response to heat and dehydration and has been postulated to have a role in the chronic kidney disease of unknown origin (CKDu) being observed in Central America. The aims of this study were to examine whether the vasopressin pathway, as measured by copeptin, is associated with the presence of kidney dysfunction, and to examine whether higher fluid intake is associated with lower circulating copeptin and thereby preserves kidney health among sugarcane workers exposed to hot conditions.

          Methods:

          Utilizing a longitudinal study of 105 workers in Guatemala, we examined relationships between hydration indices, plasma copeptin concentrations, and kidney function markers at three times during the 6-month harvest. We also examined whether baseline copeptin concentrations increased the odds of developing an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m 2.

          Results:

          Copeptin concentrations were positively associated with serum creatinine (β: 1.41, 95% CI: 0.88, 2.03) and negatively associated with eGFR (β: −1.07, 95% CI: −1.43, −0.70). In addition, as workers improved their hydration (measured by increases in fluid balance), copeptin concentrations were reduced, and this reduction was associated with an improvement in kidney function.

          Conclusions:

          Results suggest that copeptin should be studied as a potential prognostic biomarker.

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          Author and article information

          Journal
          8105511
          586
          Ann Nutr Metab
          Ann. Nutr. Metab.
          Annals of nutrition & metabolism
          0250-6807
          1421-9697
          26 March 2020
          13 March 2020
          2020
          13 March 2021
          : 76
          : 1
          : 30-36
          Affiliations
          [1 ]Center for Health, Work, & Environment, Colorado School of Public Health, University of Colorado, Aurora, CO
          [2 ]Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado, Aurora, CO
          [3 ]Colorado Consortium on Climate Change and Human Health, University of Colorado, Aurora, CO
          [4 ]Division of Renal Diseases and Hypertension, Department of Medicine, School of Medicine, University of Colorado, Aurora, CO
          [5 ]Division of Kinesiology & Health, University of Wyoming, Laramie, WY
          [6 ]Laboratory of Renal Physiopathology, Department of Nephrology. Instituto Nacional de Cardiología-Ignacio Chávez, Mexico City, Mexico
          [7 ]Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, School of Medicine, and Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO
          Author notes

          Author Contributions: Research idea and study design: JBD, LK, RJ, LN; data analysis/interpretation: JBD, MD, SB, EJ, RJ, BG, LS; statistical analysis: JBD, MD; supervision or mentorship: RJ, LN.

          Address correspondence to Jaime Butler-Dawson, Center for Health, Work, & Environment, Colorado School of Public Health. 13001 E. 17th Pl., Ste. W3111, Aurora, CO 80045. Telephone: 1-303-724-8130. Jaime.butler-dawson@ 123456cuanschutz.edu .
          Article
          PMC7212520 PMC7212520 7212520 nihpa1573672
          10.1159/000506619
          7212520
          32172243
          ea9596ac-f066-45be-9c4a-9013fa48c55c
          History
          Categories
          Article

          agricultural workers,hydration,kidney,Vasopressin
          agricultural workers, hydration, kidney, Vasopressin

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