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      Toxic effects of systemic retinoids on meibomian glands.

      1 , , , ,

      Ophthalmic research

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          Abstract

          Systemic use of retinoids is common in the treatment of various dermatological disorders. Blepharitis and conjunctivitis have been reported in 20-45% of the patients following systemic treatment with 13-cis-retinoic acid. Our purpose was to study the histopathological changes in the eyelids caused by long-term systemic treatment of female New Zealand rabbits with isotretinoin (2 mg/kg) and etretinate (2 mg/kg). The histopathological evaluation showed degenerative changes in the meibomian gland acini, leading to cell necrosis and a decrease in the basaloid cells lining the acini walls. No evidence of acute or chronic inflammatory reaction was noted.

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          Author and article information

          Journal
          Ophthalmic Res.
          Ophthalmic research
          0030-3747
          0030-3747
          1994
          : 26
          : 2
          Affiliations
          [1 ] Department of Ophthalmology, Beilinson Medical Center, Petah Tiqva, Israel.
          Article
          8196934

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