1,157
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      AMPK: a nutrient and energy sensor that maintains energy homeostasis.

      Nature reviews. Molecular cell biology
      AMP-Activated Protein Kinases, chemistry, metabolism, Adenosine Diphosphate, Adenosine Triphosphate, Animals, Appetite, physiology, Circadian Rhythm, Energy Metabolism, drug effects, Glucose, Glucose Transporter Type 4, Humans, Hypothalamus, Mammals, Mitochondria, Oxidative Stress, Xenobiotics, pharmacology

      Read this article at

      ScienceOpenPublisherPubMed
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by falling energy status, it promotes ATP production by increasing the activity or expression of proteins involved in catabolism while conserving ATP by switching off biosynthetic pathways. AMPK also regulates metabolic energy balance at the whole-body level. For example, it mediates the effects of agents acting on the hypothalamus that promote feeding and entrains circadian rhythms of metabolism and feeding behaviour. Finally, recent studies reveal that AMPK conserves ATP levels through the regulation of processes other than metabolism, such as the cell cycle and neuronal membrane excitability.

          Related collections

          Author and article information

          Comments

          Comment on this article