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      Treatment of Prediabetic Patients with Insulin: Experience and Future

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      Hormone Research
      S. Karger AG

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          Abstract

          Administration of insulin by a variety of routes can prevent the onset of diabetes and the destruction of pancreatic β-cells in prediabetic animals. Moreover, intensive insulin therapy improves β-cell function in patients with recent-onset type 1 diabetes. Preliminary trials have suggested that treatment of high-risk prediabetic patients with insulin can prevent the onset of diabetes. In addition, long-term insulin treatment appears to have no significant side-effects in non-diabetics. However, the mechanism of the protective action of insulin is not yet understood. Several large-scale controlled trials have been organized (e.g. the Diabetes Prevention Trial 1, DPT-1, and the European Paediatric Prediabetes Subcutaneous Insulin Trial, EPP-SCIT), to evaluate the effect of prophylactic insulin therapy in the prevention or delay of diabetes in high-risk paediatric individuals.

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          Author and article information

          Journal
          Hormone Research
          Horm Res
          S. Karger AG
          1423-0046
          0301-0163
          1996
          1996
          : 45
          : 1
          : 44-47
          Article
          10.1159/000184829
          d1cd364b-7f99-4e4c-84c0-95376a436982
          © 1996
          History

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