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      Lipid rafts and signal transduction.

      Nature reviews. Molecular cell biology

      metabolism, Sphingolipids, physiology, Signal Transduction, Receptors, Cell Surface, Phospholipids, Molecular Structure, Models, Biological, chemistry, Membrane Microdomains, Endocytosis, Cholesterol, Caveolae, Animals

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          Abstract

          Signal transduction is initiated by complex protein-protein interactions between ligands, receptors and kinases, to name only a few. It is now becoming clear that lipid micro-environments on the cell surface -- known as lipid rafts -- also take part in this process. Lipid rafts containing a given set of proteins can change their size and composition in response to intra- or extracellular stimuli. This favours specific protein-protein interactions, resulting in the activation of signalling cascades.

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          Journal
          10.1038/35036052
          11413487

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