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      Molecular, immunological, and biological characterization of Tityus serrulatus venom hyaluronidase: new insights into its role in envenomation.

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          Abstract

          Scorpionism is a public health problem in Brazil, and Tityus serrulatus (Ts) is primarily responsible for severe accidents. The main toxic components of Ts venom are low-molecular-weight neurotoxins; however, the venom also contains poorly characterized high-molecular-weight enzymes. Hyaluronidase is one such enzyme that has been poorly characterized.

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          Hyaluronan as an immune regulator in human diseases.

          Dianhua Jiang, Jiurong Liang, Paul Noble (2011)
          Accumulation and turnover of extracellular matrix components are the hallmarks of tissue injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety of immune cells at the injury site. Hyaluronan binds to a number of cell surface proteins on various cell types. Hyaluronan fragments signal through both Toll-like receptor (TLR) 4 and TLR2 as well as CD44 to stimulate inflammatory genes in inflammatory cells. Hyaluronan is also present on the cell surface of epithelial cells and provides protection against tissue damage from the environment by interacting with TLR2 and TLR4. Hyaluronan and hyaluronan-binding proteins regulate inflammation, tissue injury, and repair through regulating inflammatory cell recruitment, release of inflammatory cytokines, and cell migration. This review focuses on the role of hyaluronan as an immune regulator in human diseases.
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            Hyaluronidases: their genomics, structures, and mechanisms of action.

            Robert Stern, Mark Jedrzejas (2006)
            Article 0 comments Cited 211 times – based on 0 reviews     Review now
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              3V: cavity, channel and cleft volume calculator and extractor

              Neil Voss, Mark Gerstein (2010)
              As larger macromolecular structures become available, there is a growing need to understand their ‘internal’ volumes—such as deep clefts, channels and cavities—as these often play critical roles in their function. The 3V web server can automatically extract and comprehensively analyze all the internal volumes from input RNA and protein structures. It rapidly finds internal volumes by taking the difference between two rolling-probe solvent-excluded surfaces, one with as large as possible a probe radius and the other with a solvent radius (typically 1.5 Å for water). The outputs are volumetric representations, both as images and downloadable files, which can be used for further analysis. The 3V server and source code are available from http://3vee.molmovdb.org.
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                Author and article information

                Journal
                Journal ID (iso-abbrev): PLoS Negl Trop Dis
                Title: PLoS neglected tropical diseases
                Publisher: Public Library of Science (PLoS)
                ISSN (Electronic): 1935-2735
                ISSN (Print): 1935-2727
                Publication date (Electronic): Feb 2014
                Volume: 8
                Issue: 2
                Affiliations
                [1 ] Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil ; Programa de Pós-Graduação em Ciências Biológicas: Fisiologia e Farmacologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
                [2 ] Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
                [3 ] Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
                Article
                Publisher Item ID: PNTD-D-13-01361
                DOI: 10.1371/journal.pntd.0002693
                PMC ID: 3923731
                PubMed ID: 24551256
                SO-VID: 387af28f-9832-4443-bd9b-03dff653fe42
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