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      Insulin-like growth factors, insulin-like growth factor binding proteins and ovarian androgen production.

      Hormone research

      Androgens, biosynthesis, Animals, Carrier Proteins, physiology, Female, Humans, Insulin-Like Growth Factor Binding Proteins, Ovary, metabolism, Polycystic Ovary Syndrome, etiology, Somatomedins

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          Abstract

          Increasing evidence indicates that the ovary contains an insulin-like growth factor (IGF) system complete with ligands, binding proteins, and receptors. Through their interaction with IGF receptors on theca-interstitial cell surface membranes, the ligands, IGF-I and IGF-II, synergize with luteinizing hormone (LH) to increase ovarian androgen production. The actions of these growth factors are modulated by intraovarian binding proteins, especially IGFBP-1, IGFBP-2, and IGFBP-3, that enhance or inhibit the biological actions of the IGFs. These observations suggest that the IGF system plays a role in normal ovarian function and in the pathophysiology of ovarian hyperandrogenism and polycystic ovary syndrome.

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          7525445

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