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      Resolution of vitreomacular traction following intravitreal ranibizumab in cases of ocular toxoplasmosis with choroidal neovascularization.

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          Abstract

          To present the occurrence of the resolution of vitreomacular traction following intravitreal ranibizumab in two patients with inflammatory choroidal neovascular (CNV) membrane with a background of ocular toxoplasmosis.

          Most cited references10

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          The characteristic features of optical coherence tomography in posterior uveitis.

          M. J. Gallagher, T. Yilmaz, R A Cervantes-Castaneda … (2007)
          To describe the different retinal morphological characteristics that can present on optical coherence topography (OCT) in a spectrum of uveitic diseases. We reviewed the literature and our own OCT image archive for characteristic features that may be suggestive of a particular disease process. OCT demonstrates a variety of characteristic morphological changes, some that may point towards a specific disease process. We describe the various forms of macular oedema found in uveitis as well as OCT features typically found in multifocal choroiditis, serpiginous chorioretinitis, toxoplasma chorioretinitis, Vogt-Koyanagi-Harada, sympathetic ophthalmia and the vitreomacular traction syndrome. Ophthalmologists should be aware of the variety of retinal morphological characteristics that can present on OCT in uveitic disease. Recognition may aid in the diagnostic process, which is complementary to conventional fundal photography and fluorescein angiography. This can facilitate earlier diagnosis and, more importantly, the initiation of specific treatment.
          Article 0 comments Cited 34 times – based on 0 reviews     Review now
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            Upregulation of vascular endothelial growth factor in ischemic and non-ischemic human and experimental retinal disease.

            Ryan C. Schoenfeld, Lawrence W. Green, Stanley Vinores … (1996)
            Vascular endothelial growth factor (VEGF) is induced by hypoxia and it has been implicated in the development of iris and retinal neovascularization (NV) in ischemic retinopathies in which it has been suggested that Muller cells are responsible for increased VEGF production. VEGF, however, is also known to be a potent mediator of vascular permeability in other tissues and may perform this function in retina. Immunohistochemical staining for VEGF was performed on a variety of human and experimental ischemic and non-ischemic ocular disorders in which blood retinal barrier (BRB) breakdown is known to occur to determine if there is an upregulation of VEGF in these conditions. We found increased VEGF immunoreactivity in ganglion cells of rats with oxygen-induced ischemic retinopathy and in ganglion cells, the inner plexiform layer, and some cells in the inner nuclear layer of rats with experimental autoimmune uveoretinitis (EAU), in which there was no identifiable ischemia or NV. In rats with EAU, VEGF staining intensity increased from 8 to 11 days after immunization, coincident with BRB failure. These results were confirmed using two distinct anti-VEGF antibodies and by immunoblot and the immunohistochemical staining was eliminated by pre-incubating the antibodies with VEGF peptide. VEGF staining was also increased in the retina and iris of patients with ischemic retinopathies, such as diabetic retinopathy and retinal vascular occlusive disease, and in patients with disorders in which retinal ischemia does not play a major role, such as aphakic/ pseudophakic cystoid macular edema, retinoblastoma, ocular inflammatory disease or infection, and choroidal melanoma. VEGF was primarily localized within retinal neurons and retinal pigmented epithelial cells in these cases. In addition or in association with its role of inducing NV, VEGF may contribute to BRB breakdown in a variety of ocular disorders and blockage of VEGF signaling may help to reduce some types of macular edema.
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              Intravitreal ranibizumab for the treatment of inflammatory choroidal neovascularization.

              Alexander Rouvas, Petros Petrou, Maria Douvali … (2011)
              To evaluate the effect of individualized repeated intravitreal injections of ranibizumab (Lucentis) on visual acuity and central foveal thickness in patients with choroidal neovascular membrane (CNV) associated with various ocular inflammatory clinical entities.
              Article 0 comments Cited 21 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (iso-abbrev): Ther Clin Risk Manag
                Title: Therapeutics and clinical risk management
                Publisher: Informa UK Limited
                ISSN: 1176-6336
                ISSN (Print): 1176-6336
                Publication date (Electronic): 2013
                Volume: 9
                Affiliations
                [1 ] Moorfields Eye Hospital, London, UK ; Ophthalmology Department, University of Athens, Athens, Greece.
                Article
                Publisher Item ID: tcrm-9-391
                DOI: 10.2147/TCRM.S52161
                PMC ID: 3804541
                PubMed ID: 24204154
                SO-VID: 39af7596-8ede-4ba0-a91f-eb40672b3ab5
                History

                Keywords: ranibizumab,intravitreal,spontaneous resolution,vitreomacular traction,inflammation
                Data availability:
                Keywords: ranibizumab, intravitreal, spontaneous resolution, vitreomacular traction, inflammation

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