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      Chemical constituents from Gnaphalium affine and their xanthine oxidase inhibitory activity

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      Chinese Journal of Natural Medicines

      Elsevier BV

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          Abstract

          Gnaphalium affine D. Don, a medicinal and edible plant, has been used to treat gout in traditional Chinese medicine and popularly consumed in China for a long time. A detailed phytochemical investigation on the aerial part of G. affine led to the isolation of two new esters of caffeoylquinic acid named (−) ethyl 1, 4-di- O -caffeoylquinate ( 1 ) and (−) methyl 1, 4-di- O -caffeoylquinate ( 2 ), together with 35 known compounds ( 3 – 37 ). Their structures were elucidated by spectroscopic data and first-order multiplet analysis. All the isolated compounds were tested for their xanthine oxidase inhibitory activity with an in vitro enzyme inhibitory screening assay. Among the tested compounds, 1 (IC 50 11.94 μmol·L –1 ) and 2 (IC 50 15.04 μmol·L –1 ) showed a good inhibitory activity. The current results supported the medical use of the plant.

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          Author and article information

          Journal
          Chinese Journal of Natural Medicines
          Chinese Journal of Natural Medicines
          Elsevier BV
          18755364
          May 2018
          May 2018
          : 16
          : 5
          : 347-353
          Article
          10.1016/S1875-5364(18)30066-9
          © 2018

          https://www.elsevier.com/tdm/userlicense/1.0/

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