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      Chemical constituents from Gnaphalium affine and their xanthine oxidase inhibitory activity

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      Chinese Journal of Natural Medicines
      Elsevier BV

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          Abstract

          Gnaphalium affine D. Don, a medicinal and edible plant, has been used to treat gout in traditional Chinese medicine and popularly consumed in China for a long time. A detailed phytochemical investigation on the aerial part of G. affine led to the isolation of two new esters of caffeoylquinic acid named (−) ethyl 1, 4-di- O -caffeoylquinate ( 1 ) and (−) methyl 1, 4-di- O -caffeoylquinate ( 2 ), together with 35 known compounds ( 3 – 37 ). Their structures were elucidated by spectroscopic data and first-order multiplet analysis. All the isolated compounds were tested for their xanthine oxidase inhibitory activity with an in vitro enzyme inhibitory screening assay. Among the tested compounds, 1 (IC 50 11.94 μmol·L –1 ) and 2 (IC 50 15.04 μmol·L –1 ) showed a good inhibitory activity. The current results supported the medical use of the plant.

          Author and article information

          Journal
          Chinese Journal of Natural Medicines
          Chinese Journal of Natural Medicines
          Elsevier BV
          18755364
          May 2018
          May 2018
          : 16
          : 5
          : 347-353
          Article
          10.1016/S1875-5364(18)30066-9
          7f7d7078-cd3f-4178-b45d-712ccf8c517b
          © 2018

          https://www.elsevier.com/tdm/userlicense/1.0/

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