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Abstract
Gnaphalium affine D. Don, a medicinal and edible plant, has been used to treat gout
in traditional Chinese medicine and popularly consumed in China for a long time. A
detailed phytochemical investigation on the aerial part of G. affine led to the
isolation of two new esters of caffeoylquinic acid named (−) ethyl 1, 4-di- O -caffeoylquinate
( 1 ) and (−) methyl 1, 4-di- O -caffeoylquinate ( 2 ), together with 35 known compounds
( 3 – 37 ). Their structures were elucidated by spectroscopic data and first-order
multiplet analysis. All the isolated compounds were tested for their xanthine oxidase
inhibitory activity with an in vitro enzyme inhibitory screening assay. Among the
tested compounds, 1 (IC 50 11.94 μmol·L –1 ) and 2 (IC 50 15.04 μmol·L –1 )
showed a good inhibitory activity. The current results supported the medical use of
the plant.
Author and article information
Journal
Title:
Chinese Journal of Natural Medicines
Abbreviated Title:
Chinese Journal of Natural Medicines